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Poster display session

2794 - Single Nucleotide Polymorphisms in PD-L1 and outcome in Nivolumab-treated Advanced Non-Small-Cell Lung Cancer Patients

Date

10 Sep 2017

Session

Poster display session

Presenters

Takashi Nomizo

Citation

Annals of Oncology (2017) 28 (suppl_5): v403-v427. 10.1093/annonc/mdx376

Authors

T. Nomizo, T. Funazo, H. Ozasa, T. Tsuji, Y. Yasuda, H. Yoshida, Y. Sakamori, H. Nagai, T. Hirai, Y.H. Kim

Author affiliations

  • Respiratory Medicine, Kyoto University-Graduate school of medicine, 606-8507 - Kyoto/JP
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Resources

Abstract 2794

Background

Nivolumab is an established agent in the management of non-small-cell lung cancer (NSCLC); however, while some patients with lung cancer have marked responses to nivolumab, others do not respond. To determine the efficacy of nivolumab, we retrospectively evaluated treatment response with respect to PD-1/PD-L1 SNPs among patients with NSCLC.

Methods

Between December 2015 and October 2016, a total of 68 patients with histologically or cytologically confirmed NSCLC were treated with nivolumab. Among these 68 patients, all of whom were registered at Kyoto University Hospital. Genomic DNA was extracted from peripheral blood and genotyping was performed using real-time PCR method. We investigated the possible correlation of PD-1/PD-L1 SNPs with PFS (progression-free survival) using Kaplan-Meier method.

Results

A total of 68 patients were evaluated for clinical response. The G allele of PD-L1 rs2282055 was significantly associated with better clinical response. The median PFS time was 4.2 months (95% confidence interval [CI], 1.7 months to 3.9 months) for the G/G and G/T genotypes of rs2282055 and 2.0 months (95% confidence interval [CI], 0.9 months to 2.2 months) for the T/T genotype (P = 0.0388). Moreover, the T/T and C/T genotypes of PD-L1 rs1411262 were significantly associated with better PFS in NSCLC patients treated with nivolumab.

Conclusions

The G/G and G/T genotypes of PD-L1 rs2282055 were significantly associated with better ORR and PFS in NSCLC patients treated with nivolumab. These results suggest that PD-L1 SNPs may be a biomarker for the efficacy of nivolumab.

Clinical trial identification

Legal entity responsible for the study

Kyoto University

Funding

None

Disclosure

All authors have declared no conflicts of interest.

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