Abstract 5064
Background
PALETTE was a randomized phase 3 trial (NCT00753688) that demonstrated single-agent activity of PAZ in advanced STS (aSTS). We evaluated the relationship between age, prior lines of therapy, and dose modifications on the safety and efficacy of PAZ in aSTS.
Methods
Median progression-free survival (mPFS) was evaluated in subgroups of prior lines of therapy (1 prior line; 2+ prior lines), age (
Results
A total of 246 patients received pazopanib in the PALETTE study. Median PFS and median overall survival (OS) were longer in patients receiving PAZ who had only 1 prior line of therapy vs 2+ prior lines of therapy (mPFS, 24.7 vs 18.9 weeks [Table]; OS, 13.7 vs 11.3 months). In patients receiving PAZ, mPFS was similar in ages
Conclusions
Longer mPFS was observed in patients receiving PAZ following only 1 line of therapy. Additionally, mPFS with PAZ was maintained regardless of patient age or if dose modification was required to manage toxicity.
Clinical trial identification
NCT00753688
Legal entity responsible for the study
Novartis Pharmaceutical Corporation
Funding
Novartis Pharmaceutical Corporation
Disclosure
A. Le Cesne: Pharmamar, Lilly, Pfizer, Novartis, Amgen. S. Bauer: Research support: Novartis, Blueprint Medicines, Ariad. Ad board: GSK, Novartis, Pfizer, Bayer, Fresenius, Lilly, Blueprint Medicines, Deciphera. CME-Honoraria: Pharmamar, GSK, Bayer, Novartis. Travel support: Pharmamar, Bayer. G.D.S. Demetri: Grants and personal fees from Novartis, during the conduct of the study; grants and personal fees from Janssen, Eisai, Eli Lilly and PharmaMar, outside the submitted work. W.T.A. van der Graaf: Research grants: GSK, Novartis. Advisory board: Bayer. G. Han, L. Dezzani, Q. Ahmad: Employee of Novartis. H. Gelderblom: Grants to institution LUMC, during the conduct of the study.