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Poster display session

2066 - Safety and efficacy of S-1 treatment in elderly patients with advanced or recurrent gastric cancer: a subgroup analysis from the phase III JFMC36-0701 trial

Date

09 Sep 2017

Session

Poster display session

Presenters

Kazuhiro Nishikawa

Citation

Annals of Oncology (2017) 28 (suppl_5): v209-v268. 10.1093/annonc/mdx369

Authors

K. Nishikawa1, S. Yoshino2, S. Morita3, T. Takahashi4, K. Sakata5, J. Nagao6, H. Nemoto7, N. Murakami8, H. Hasegawa9, R. Shimizu10, T. Yoshikawa11, H. Osanai12, M. Imano13, H. Naitoh14, A. Tanaka15, J. Sakamoto16, S. Saji17, M. Oka18

Author affiliations

  • 1 Surgery, National Hospital Organization Osaka National Hospital, 540-0006 - Osaka/JP
  • 2 Oncology Center, Yamaguchi University Hospital, Ube/JP
  • 3 Biomedical Statistics And Bioinformatics, Graduate School of Medicine, Kyoto University, Kyoto/JP
  • 4 Gastroenterological Surgery, Osaka University Graduate School of Medicine, Suita/JP
  • 5 Digestive Surgery, Shimonoseki Medical Center, Shimonoseki/JP
  • 6 Surgery, Toho University Omori Medical Center, Tokyo/JP
  • 7 Surgery, Showa University Fujigaoka Hospital, Yokohama/JP
  • 8 Palliative Care And Surgery, Koseiren Takaoka Hospital, Takaoka/JP
  • 9 Surgery, Ogori Daiichi General Hospital, Yamaguchi/JP
  • 10 Surgery, Onoda Red Cross Hospital, Sanyo-Onoda/JP
  • 11 Department Of Gastrointestinal Surgery, Kanagawa Cancer Center, 2418515 - Yokohama/JP
  • 12 Surgery, Sapporo Geka Kinen Hospital, Sapporo/JP
  • 13 Surgery, Kindai University Faculty of Medicine, Osakasayama/JP
  • 14 Surgery, Japan community health care organization Gunma Chuo Hospital, Maebashi/JP
  • 15 Surgery, Mine City Hospital, Mine/JP
  • 16 Chairperson Of The Institutional Review Board, Japanese Foundation for Multidisciplinary Treatment of Cancer, Tokyo/JP
  • 17 Chairman, Japanese Foundation for Multidisciplinary Treatment of Cancer, Tokyo/JP
  • 18 The President, Yamaguchi University, Yamaguchi/JP
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Resources

Abstract 2066

Background

Chemotherapy is often considered for elderly patients with advanced or recurrent gastric cancer. However, there are no prospective trials evaluating outcomes of chemotherapy in elderly patients with gastric cancer. Safety and efficacy of S-1 treatment in elderly versus younger patients were evaluated in the phase III JFMC36-0701 trial.

Methods

Between February 2007 and June 2010, 309 patients with advanced or recurrent gastric cancer were randomly assigned to S-1alone or S-1plus lentinan treatment; 134 patients (43.4%) enrolled were ≥75 years of age (range, 75-94) and 175 (56.6%) were 

Results

Patient characteristics were comparable between the two cohorts. OS was 12.8 (95% CI 10.7-14.9) and 11.5 (95% CI 9.5-13.4) months for patients aged ≥75 and 

Conclusions

This subgroup analysis suggests that elderly patients with advanced or recurrent gastric cancer derive similar benefit from S-1 treatment to younger patients, with acceptable toxicity.

Clinical trial identification

UMIN 000000574

Legal entity responsible for the study

Japanese Foundation for Multidisciplinary Treatment of Cancer

Funding

Japanese Foundation for Multidisciplinary Treatment of Cancer

Disclosure

K. Nishikawa: Personal fees from Taiho, Chugai, Lilly, Yakult, Ajinomoto, outside the submitted work. S. Yoshino: Personal fees from Taiho, MSD, Chugai, Eli Lilly, Ono, outside the submitted work. S. Morita: Personal fees from Taiho, outside the submitted work. T. Yoshikawa: Personal fees from Taiho, Chugai, Yakult, Ono, MSD, outside the submitted work. All other authors have declared no conflicts of interest.

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