Evidence regarding whether long term survivors (≥ 5 years) of adult cancers (LSAC) have a higher risk of mood disorders than the general population is not consistent. We aimed to compare the mood disorder rates between the two cohorts and to identify potential risk factors.
We conducted a retrospective population-based cohort study using the Taiwan National Health Insurance Research Database. We identified LSAC who were newly diagnosed between January 1, 2000 and December 31, 2007. One control was matched per patient for age, sex, index date, and the Charlson comorbidity index (CCI). The primary outcome was diagnosis of mood disorders during the follow-up period. Cumulative incidences and sub-hazard ratios (SHR) were calculated and multivariate analyses were conducted after adjusting for mortality.
We identified 190,748 LSAC and 190,748 controls. The mood disorder risk was significantly higher in the LSAC cohort than in the control cohort (adjusted SHR = 1.16, 95% confidence interval [CI] = 1.13–1.18, P
Long-term cancer survivors have an increased risk of mood disorders and therefore should be followed-up for depresison especially in those with certain site-specific cancer types.
Clinical trial identification
Legal entity responsible for the study
Chang Gung Medical Foundation, Chang Gung Memorial Hospital at Linkou
All authors have declared no conflicts of interest.