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Poster display session

1740 - Real world data about Clinical efficacy and safety of Apatinib in the treatment of advanced gastric cancer

Date

09 Sep 2017

Session

Poster display session

Presenters

jifeng feng

Citation

Annals of Oncology (2017) 28 (suppl_5): v209-v268. 10.1093/annonc/mdx369

Authors

J. feng1, B. Shen1, Z. He2, L. Deng3, A. Dai4, X. Shen5, L. Chen1, H. Jiang6, X. Li7, G. Zhou1, J. Yu8, L. Yang9, P. Chen10, M. Zhuang11

Author affiliations

  • 1 Medical Oncology, Jiang Su Cancer Hospital, 210009 - nanjing/CN
  • 2 Medical Oncology, Suzhou Municipal Hospital, 215000 - Suzhou/CN
  • 3 Medical Oncology, Jiang Su Cancer Hospital, 214400 - Jiangyin/CN
  • 4 Medical Oncology, Traditional Chinese Medicine Hospital of Kunshan, 215300 - Kunshan/CN
  • 5 Medical Oncology, The Second Affiliated Hospital of Suzhou University, 215004 - Suzhou/CN
  • 6 Medical Oncology, The Second People’s Hospital of Changzhou, 213003 - Changzhou/CN
  • 7 Medical Oncology, Affiliated Hospital of Jiangsu University, 212001 - Zhenjiang/CN
  • 8 Medical Oncology, New Area Branch of The Third People’s Hospital of Xinghua, 225799 - Xinghua/CN
  • 9 Medical Oncology, Nantong Tumor Hospital, 226000 - Nantong/CN
  • 10 Medical Oncology, The First People’s Hospital of Yancheng, 224005 - Yancheng/CN
  • 11 Medical Oncology, The First People’s Hospital of Lianyungang, 222002 - Lianyungang/CN
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Resources

Abstract 1740

Background

Observation study is difference with randomized controlled trial and reflects the real world data in clinical practice with larger sample size, wider inclusion criteria, various interventions and long-term follow-up. We analyzed the real world data achieve real world evidence, which was applied to analyze discuses, patients, treatment patterns, resource utilization and outcome. The aim of this study was to evaluate the efficacy and safety of apatinib in real world, and provide a decision reference for Clinical practice.

Methods

This was a prospective, multicenter, non-intervention registered study. The patients (pts), were ≥18 years old, with histologically confirmed advanced gastric cancer (GC) or adenocarcinoma of esophagogastric junction (AEG), two or more lines of prior chemotherapy. All the pts were orally given apatinib at an initial dose of 500 mg until disease progression or death. Dose adjustment was allowed.

Results

The 230 pts, included 164 males and 66 female were eligible, the average age of pts was 62 years old, stage IV was the mainly clinical stage, the main ECOG performance status was 1, 54.78% pts were given apatinib 500 mg qd. 63.91% pts were received chemotherapy along with apatinib. In the 230 pts, there were 125 received efficacy evaluation. 8 pts achieved partial response (PR), 64 had stable disease (SD), and 53 had progressive disease (PD). The objective response rate (ORR) was 6.4% and the disease control rate (DCR) was 57.6%. The middle progression free survival (mPFS) and middle overall survival (mOS) were 3.3 months and 6.3 months, respectively. Compared with the non chemotherapy, chemotherapy achieved a longer mPFS (3.8months VS 2.9 months) and mOS (8.3months VS 5.0 months). 211 pts were included for safety analysis. The incidence of adverse events (AEs) was 91.2%, The grade 3 and 4 was 62.3%. The incidence of serious adverse events (SAE) was 17.2%. Main AEs were hypertension, Hand-foot syndrome, proteinuria and fatigue. Pts received chemotherapy achieved a better tolerance.

Conclusions

The real world data show that apatinib treatment significantly improved OS and PFS with an acceptable safety profile in patients with advanced gastric cancer.

Clinical trial identification

ChiCTR-OPN-15006601

Legal entity responsible for the study

Jiang Su Cancer Hospital

Funding

None

Disclosure

All authors have declared no conflicts of interest.

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