Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Poster display session

4799 - Proteomics of Triple Negative Breast Cancer Developing Metastases to Central Nervous System.

Date

11 Sep 2017

Session

Poster display session

Presenters

Katerin Rojas

Citation

Annals of Oncology (2017) 28 (suppl_5): v573-v594. 10.1093/annonc/mdx390

Authors

K. Rojas1, L. Trilla-Fuertes2, A. Gámez3, J. Sepulveda Sanchez1, L. Manso Sánchez1, G. Prado-Vásquez3, C. Chiva4, A. Zapater-Moros3, S. Llorente-Armijo3, D.C. Mendiola1, E. Sabidó4, J.A. Fresno3, E.M. Ciruelos Gil1, L. Paz-Ares1

Author affiliations

  • 1 Medical Oncology, University Hospital 12 De Octubre, 28041 - Madrid/ES
  • 2 Biology, Biomedica Molecular Medicine, Madrid/ES
  • 3 Molecular Oncology&pathology Lab. Ingemm., Hospital La Paz, Madrid/ES
  • 4 Proteomics Unit, Barcelona Institute of Science and Technology(BIST), Barcelona/ES
More

Resources

Abstract 4799

Background

Breast cancer (BC) is the most frequent tumor in woman, representing 20-30% of all malignancies and continues being the first reason of death for cancer in European women. Triple negative (TN) BC present minor survival rates than other BC subtypes. Key reasons for that is the absence of predictive markers of response to current therapy and the absence of targeted therapies. This study aims to identify proteins with predictive value of central Nervous System (CNS) metastases and therapeutic target candidates.

Methods

This is a case-control retrospective study comparing patients (pts) with metastases to CNS vs pts without them after adjuvant treatment. Sample selection included 50 samples. Formalin-fixed, paraffin-embedded samples were retrieved from Hospital 12 de Octubre Biobank. Proteins were quantified by parallel reaction monitoring.

Results

The average age was 55 years (range 25-85). Forty-seven pts (88.67%) had ductal histology and presented high grade tumors (40 pts; 75.47%). Eight women in the case group presented as first distant recurrence CNS (34.80%), local recurrence (3pts, 13.04%), lung (2pt; 8.7%), bone (1pt; 4.34%) and other locations (7pts; 30.38%). In the control group, first distant recurrence occurred locally (6pts; 46.1%), bone (2pts; 15.4%), lung (1pt; 7.7%) and other sites (4pts; 23.1%). Protein expression data was successfully obtained from 50 samples. ISG15 ubiquitin-like modifier, (P05161) was overexpressed in triple negative breast cancer tumors that develop metastases to CNS (p = 0.036) compared to tumors that do not develop these CNS metastases.

Conclusions

TN tumors frequently metastasize to visceral organs, particularly lungs and brain, and are less likely to metastasize to bone. The interferon-stimulated gene 15 ubiquitin-like modifier (ISG15) encodes an IFN-inducible, ubiquitin-like protein. The ISG15 protein is involved in numerous cellular functions, including interferon-induced immune responses and the regulation of cellular protein turnover. Therefore, ISG15 may represent a novel breast tumor marker helpful in selecting pts who will develop CNS metastases. It also should be explored as a therapeutic target in this clinical context.

Clinical trial identification

Legal entity responsible for the study

Biomedica Molecular Medicine SL.

Funding

None.

Disclosure

L. Trilla-Fuertes: Employee of Biomedica Molecular Medicine SL. A. Gámez, J.A. Fresno: Shareholders in Biomedica Molecular Medicine SL. All other authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences.