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Poster display session

2900 - Prognostic estimates of Ki-67 percentage drop after neoadjuvant chemotherapy (NAC) in luminal B (lumB) and triple negative breast cancer (TNBC)

Date

11 Sep 2017

Session

Poster display session

Presenters

Javier Pascual

Citation

Annals of Oncology (2017) 28 (suppl_5): v68-v73. 10.1093/annonc/mdx364

Authors

J. Pascual1, B. Rojas-Garcia1, V. Peg2, S. Diaz-Botero3, E. Zamora1, E. Muñoz Couselo1, M. Oliveira1, P. Gomez Pardo1, J. Perez Garcia1, F. Ruiz-Pace4, C. VIAPLANA4, S. Escrivá1, L. Garrigos1, M. Arumi1, M. Espinosa-Bravo3, J. Cortés5, I. Rubio3, C. Saura1, R. Dienstmann4, M. Bellet Ezquerra1

Author affiliations

  • 1 Medical Oncology Department, Vall d’Hebron University Hospital Institute of Oncology (VHIO), 08035 - Barcelona/ES
  • 2 Anatomical Pathology, Vall d'Hebron University Hospital, Barcelona/ES
  • 3 Breast Pathology Unit, Vall d'Hebron University Hospital, 08035 - Barcelona/ES
  • 4 Oncology Data Science Group (odyssey), Vall d'Hebron Institute of Oncology (VHIO), 08035 - Barcelona/ES
  • 5 Medical Oncology Department, Vall d’Hebron University Hospital Institute of Oncology (VHIO), 08035 - barcelona/ES
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Resources

Abstract 2900

Background

Pathologic complete response (pCR) and residual cancer burden (RCB) after NAC are validated prognostic markers in BC. We assessed the impact of adding Ki-67% drop (baseline biopsy - surgery) to distant metastasis relapse-free survival (dRFS) models containing CP factors plus post-treatment stage (MDACC CPS score), estrogen receptor status and tumor grade (MDACC CPS+EG score).

Methods

Records from 341 patients (pts) with lumB/HER2 neg (baseline Ki67 >20%) or TNBC who received NAC from 2008 to 2015 at our hospital were reviewed. Uni- and multivariate Cox models were constructed and concordance-index (c-index) calculated.

Results

Pts: median age 47 years (24-83), 60% lumB and 40% TNBC, 62% stage 2, 38% stage 3. pCR: 12% lumB, 32% TNBC (p 

Conclusions

Our data support the addition of Ki-67% drop after NAC in lumB and TNBC to existing dRFS online outcome calculators. In the context of RCB 2/3, Ki-67 > = 20% drop is mainly seen in lumB/HER neg tumors. Importantly, Ki-67 < 20% drop identifies a high-risk population that may be eligible to clinical trials with novel therapeutic interventions in the adjuvant setting.

Clinical trial identification

Legal entity responsible for the study

Vall d'Hebron University Hospital

Funding

Vall d'Hebron Institute of Oncology

Disclosure

M. Oliveira: Consulting or Advisory Role in Roche-Genentech and Puma Biotechnology. Research Funding in AstraZeneca and Genentech/Roche. R. Dienstmann: Consulting or Advisory Role in Roche-Genentech and in Astellas Pharma. Research Funding in Merck. All other authors have declared no conflicts of interest.

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