Loco-regional recurrence (LRR) of breast cancer is a significant cause of morbidity and mortality. It is poorly described how prognosis after LRR has evolved over time at the population level.
2272 patients diagnosed with LRR between 1980-2014 were identified within the Stockholm cancer registry and divided in 7 cohorts by the year of LRR diagnosis. Post-relapse event free survival (EFS) and overall survival (OS) were analyzed separately in local and loco-regional relapses and compared across the cohorts by Cox regression method. Primary tumor size, axillary node status, estrogen receptor (ER) status, type of surgery, adjuvant chemotherapy, LRR free survival, and age at LRR were the covariates for Cox model adjustment.
In 1615 patients diagnosed with local relapse, 903 post-LRR events were registered (Table). A significant improvement in median EFS (p < .001) and OS (p < .001) was observed in patients diagnosed 2010-14 compared with previous time periods. Among 657 patients with loco-regional recurrences, 476 experienced a post-LRR event (Table). EFS and OS independently improved over time (p
Survival after LRR has gradually improved over the last 35 years regardless of other recognized prognostic factors.
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All authors have declared no conflicts of interest.