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Poster display session

2206 - Prognosis after loco-regional recurrence of breast cancer: 35 years longitudinal data from the Stockholm cancer register.

Date

11 Sep 2017

Session

Poster display session

Presenters

Claudette Falato

Citation

Annals of Oncology (2017) 28 (suppl_5): v74-v108. 10.1093/annonc/mdx365

Authors

C. Falato1, L. Eriksson1, A. Sofiadis1, S.K. Taylor2, A. Nordblom1, I. Fredriksson3, J. Hartman1, J. Bergh1, T. Foukakis1

Author affiliations

  • 1 Oncology And Pathology, Karolinska University Hospital-Solna, 17176 - Stockholm/SE
  • 2 Dep Of Medical Oncology, BC Cancer Agency, Kelowna BC/CA
  • 3 Molecular Medicine And Surgery, Karolinska University Hospital-Solna, 17176 - Stockholm/SE
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Resources

Abstract 2206

Background

Loco-regional recurrence (LRR) of breast cancer is a significant cause of morbidity and mortality. It is poorly described how prognosis after LRR has evolved over time at the population level.

Methods

2272 patients diagnosed with LRR between 1980-2014 were identified within the Stockholm cancer registry and divided in 7 cohorts by the year of LRR diagnosis. Post-relapse event free survival (EFS) and overall survival (OS) were analyzed separately in local and loco-regional relapses and compared across the cohorts by Cox regression method. Primary tumor size, axillary node status, estrogen receptor (ER) status, type of surgery, adjuvant chemotherapy, LRR free survival, and age at LRR were the covariates for Cox model adjustment.

Results

In 1615 patients diagnosed with local relapse, 903 post-LRR events were registered (Table). A significant improvement in median EFS (p < .001) and OS (p < .001) was observed in patients diagnosed 2010-14 compared with previous time periods. Among 657 patients with loco-regional recurrences, 476 experienced a post-LRR event (Table). EFS and OS independently improved over time (p

Conclusions

Survival after LRR has gradually improved over the last 35 years regardless of other recognized prognostic factors.

Clinical trial identification

Legal entity responsible for the study

Karolinska Institutet

Funding

Dagmar Ferbsminnesfond

Disclosure

All authors have declared no conflicts of interest.

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