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Poster display session

2812 - Primary results of a study to evaluate a decision aid for women offered neoadjuvant systemic therapy for breast cancer

Date

10 Sep 2017

Session

Poster display session

Presenters

Nicholas Zdenkowski

Citation

Annals of Oncology (2017) 28 (suppl_5): v507-v510. 10.1093/annonc/mdx384

Authors

N. Zdenkowski1, P. Butow2, A.J. Spillane3, C. Douglas4, C. Beckmore5, M. Jones6, F.M. Boyle3

Author affiliations

  • 1 Medical Oncology, Calvary Mater Hospital Newcastle, 2298 - Newcastle/AU
  • 2 Psychology, University of Sydney, Sydney/AU
  • 3 Medicine, University of Sydney, Sydney/AU
  • 4 Medicine, University of Newcastle, Newcastle/AU
  • 5 Trials Coordination, Australia and New Zealand Breast Cancer Trials Group, Newcastle/AU
  • 6 Clinical Research And Statistical Support Unit, Hunter Medical Research Institute, Newcastle/AU
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Resources

Abstract 2812

Background

Women diagnosed with large or highly proliferative operable breast cancer may be offered neoadjuvant systemic therapy (NAST) for reasons including downstaging, prognostication or expanding surgical options. We aimed to systematically develop, and evaluate a DA for women who had been offered NAST.

Methods

Eligible women who were considered candidates for NAST, from four Australian recruiting centres were enrolled in a single arm longitudinal study. Participants completed online questionnaires prior to accessing the DA, and on three occasions post-DA. Primary outcomes were feasibility of use, and acceptability to patients and clinicians. Secondary outcomes were patient reported measures relevant to patient decision-making.

Results

Seventy-nine women were offered study participation and 59 enrolled. Patients were typically well educated, married, had health insurance and were information seekers (mean information needs: 7.5/10; SD 1.84). 59/79 (74.7%) patients who were offered study participation accessed the DA and 49 (79.7%) of those 59 participants reported having read it. 41/51 (80.4%) participants who completed the post-DA assessment reported that the DA helped them with their decision about NAST. 51/59 (86%) participants elected to receive NAST. 16/18 (88.9%) investigators would continue to use the DA in routine practice. Post-DA, decisional conflict decreased significantly across all subscales (p 

Conclusions

Study primary outcomes were positive, showing the DA was feasible and acceptable to patients and clinicians. Improvements in decision-related outcomes were demonstrated, and the DA could be included in routine workflow. This DA can be implemented into routine clinical practice for women with operable breast cancer who are candidates for NAST.

Clinical trial identification

Registration: Australia and New Zealand Clinical Trials Registry (www.anzctr.org.au): ACTRN12614001267640

Legal entity responsible for the study

Australia and New Zealand Breast Cancer Trials Group

Funding

HCF Research Foundation Australia and New Zealand Breast Cancer Trials Group

Disclosure

All authors have declared no conflicts of interest.

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