Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Poster display session

2812 - Primary results of a study to evaluate a decision aid for women offered neoadjuvant systemic therapy for breast cancer


10 Sep 2017


Poster display session


Nicholas Zdenkowski


Annals of Oncology (2017) 28 (suppl_5): v507-v510. 10.1093/annonc/mdx384


N. Zdenkowski1, P. Butow2, A.J. Spillane3, C. Douglas4, C. Beckmore5, M. Jones6, F.M. Boyle3

Author affiliations

  • 1 Medical Oncology, Calvary Mater Hospital Newcastle, 2298 - Newcastle/AU
  • 2 Psychology, University of Sydney, Sydney/AU
  • 3 Medicine, University of Sydney, Sydney/AU
  • 4 Medicine, University of Newcastle, Newcastle/AU
  • 5 Trials Coordination, Australia and New Zealand Breast Cancer Trials Group, Newcastle/AU
  • 6 Clinical Research And Statistical Support Unit, Hunter Medical Research Institute, Newcastle/AU


Abstract 2812


Women diagnosed with large or highly proliferative operable breast cancer may be offered neoadjuvant systemic therapy (NAST) for reasons including downstaging, prognostication or expanding surgical options. We aimed to systematically develop, and evaluate a DA for women who had been offered NAST.


Eligible women who were considered candidates for NAST, from four Australian recruiting centres were enrolled in a single arm longitudinal study. Participants completed online questionnaires prior to accessing the DA, and on three occasions post-DA. Primary outcomes were feasibility of use, and acceptability to patients and clinicians. Secondary outcomes were patient reported measures relevant to patient decision-making.


Seventy-nine women were offered study participation and 59 enrolled. Patients were typically well educated, married, had health insurance and were information seekers (mean information needs: 7.5/10; SD 1.84). 59/79 (74.7%) patients who were offered study participation accessed the DA and 49 (79.7%) of those 59 participants reported having read it. 41/51 (80.4%) participants who completed the post-DA assessment reported that the DA helped them with their decision about NAST. 51/59 (86%) participants elected to receive NAST. 16/18 (88.9%) investigators would continue to use the DA in routine practice. Post-DA, decisional conflict decreased significantly across all subscales (p 


Study primary outcomes were positive, showing the DA was feasible and acceptable to patients and clinicians. Improvements in decision-related outcomes were demonstrated, and the DA could be included in routine workflow. This DA can be implemented into routine clinical practice for women with operable breast cancer who are candidates for NAST.

Clinical trial identification

Registration: Australia and New Zealand Clinical Trials Registry (www.anzctr.org.au): ACTRN12614001267640

Legal entity responsible for the study

Australia and New Zealand Breast Cancer Trials Group


HCF Research Foundation Australia and New Zealand Breast Cancer Trials Group


All authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences.