Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Supportive and palliative care

4296 - Pre-Chemotherapy Nutritional status and chemotherapy response: An Observational Study.

Date

09 Sep 2017

Session

Supportive and palliative care

Presenters

Vijay Agarwal

Citation

Annals of Oncology (2017) 28 (suppl_5): v543-v567. 10.1093/annonc/mdx388

Authors

R. Rao1, N. Saha2, V. Mani1, R. Amritanshu1, R. Geetha1, N. Radheshyam3, S. Patil3, H.P. Shashidhara4, T.C. Satheesh3, V. Agarwal3, B.S. Ajaikumar3

Author affiliations

  • 1 Healthcare Global Enterprises Ltd., CARE, HCG Foundation, 560027 - BANGALORE/IN
  • 2 Nutrition, Healthcare Global Enterprises ltd., 560027 - BANGALORE/IN
  • 3 Medical Oncology, Healthcare Global Enterprises ltd., 560027 - BANGALORE/IN
  • 4 Medical Oncology, HCG Bangalore Institute of Oncology Speciality Centre, 560027 - Bangalore/IN
More

Resources

Login to access the resources on OncologyPRO.

If you do not have an ESMO account, please create one for free.

Abstract 4296

Background

Cancer patients undergoing chemotherapy suffer from nausea, vomiting, low blood counts and electrolyte disturbances that impose stress on the nutritional needs of cancer patients. Nutritional status has been shown to reflect not just the patient’s general condition but also to predict patient survival. In this study, we evaluate the predictive effects of pre-chemotherapy nutritional status in patients with solid malignancies on chemotherapy response and quality of life.

Methods

Two hundred adult patients with localized solid malignancies (Except GI and Brain malignancies) undergoing Neoadjuvant/adjuvant chemotherapy were analyzed for their nutritional status before the therapy. Nutritional status was assessed using Subjective Global assessment (SGA), Nutritional risk index (NRI), Body mass Index (BMI), Platelet lymphocyte ratio (PLR), neutrophil-lymphocyte ratio (NLR), and Albumin-globulin ratio (AGR) prior to their chemotherapy treatment. Patients were also assessed for Hand grip strength, Quality of life using Functional assessment of Chronic illness Therapy (FACIT) and EUROQol C30 and radiological response using RECIST criteria following chemotherapy.

Results

Mean age of study population was 51.65 ± 10.1years. Multivariate regression analysis was done on Chemotherapy outcomes such as Response criteria, FACIT scores, Quality of life scores and handgrip strength using, SGA, NRI, NLR, BMI and Albumin/Globulin ratio as predictors. SGA score emerged as a significant primary predictor for hand grip strength (β=-7.3, p 

Conclusions

The results suggest that pre-chemotherapy nutritional status and NLR influence the functional quality of life, strength and chemotherapy response in patients with solid malignancies.

Clinical trial identification

Legal entity responsible for the study

Raghavendra Rao M

Funding

HCG Foundation

Disclosure

All authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences.