Cancer patients undergoing chemotherapy suffer from nausea, vomiting, low blood counts and electrolyte disturbances that impose stress on the nutritional needs of cancer patients. Nutritional status has been shown to reflect not just the patient’s general condition but also to predict patient survival. In this study, we evaluate the predictive effects of pre-chemotherapy nutritional status in patients with solid malignancies on chemotherapy response and quality of life.
Two hundred adult patients with localized solid malignancies (Except GI and Brain malignancies) undergoing Neoadjuvant/adjuvant chemotherapy were analyzed for their nutritional status before the therapy. Nutritional status was assessed using Subjective Global assessment (SGA), Nutritional risk index (NRI), Body mass Index (BMI), Platelet lymphocyte ratio (PLR), neutrophil-lymphocyte ratio (NLR), and Albumin-globulin ratio (AGR) prior to their chemotherapy treatment. Patients were also assessed for Hand grip strength, Quality of life using Functional assessment of Chronic illness Therapy (FACIT) and EUROQol C30 and radiological response using RECIST criteria following chemotherapy.
Mean age of study population was 51.65 ± 10.1years. Multivariate regression analysis was done on Chemotherapy outcomes such as Response criteria, FACIT scores, Quality of life scores and handgrip strength using, SGA, NRI, NLR, BMI and Albumin/Globulin ratio as predictors. SGA score emerged as a significant primary predictor for hand grip strength (β=-7.3, p
The results suggest that pre-chemotherapy nutritional status and NLR influence the functional quality of life, strength and chemotherapy response in patients with solid malignancies.
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Legal entity responsible for the study
Raghavendra Rao M
All authors have declared no conflicts of interest.