To analize the results of adjuvant and salvage radiotherapy after radical prostatectomy and to determine prognostic factors of biochemical relapse free survival (BRFS).
302 patients were treated at our institution over a 12-year period. Overall survival and biochemical-relapse free survival were calculated using Kaplan-Meier and multivariate Cox regression analysis was used to assess differences between groups.
Mean age at diagnosis was 65 years (42-80). All patients underwent radical prostatectomy combined with pelvic lymphadenectomy in 47.1% of cases. Adjuvant RT was performed in 113 patients and salvage RT in 183 (9 for local recurrence). The distribution of patients by pT stage was pT2a-b(30.3%), pT2c (35%), pT3(29%) and pT4(2.3%). Upgrade in Gleason score between biopsy and prostatectomy was experienced by 46.7% of patients. Positive surgical margins were reported in 56.5% of cases. Neoadjuvant androgen ablation before surgery was given to 36.5%. Mean pre-RT PSA of 0.46ng/ml (0-12.8) and mean dosis to surgical bed was of 70Gy (60-76Gy). Mean follow-up was 58.85 months (1-153 months). Overall survival at 5 and 10 years was 98.1% and 94.3%, respectively and BRFS at 5 and 10 years was 76.5% vs. 61.8%, respectively. The timing of RT (ART vs. SRT) and pre-RT PSA
Postoperative radiation therapy provides excellent long-term overall survival with an aceptable BRFS. Pre-RT PSA
Clinical trial identification
Legal entity responsible for the study
Hospital Ramón y Cajal
All authors have declared no conflicts of interest.