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Poster display session

3513 - Polyethylene Glycol embolics loaded with irinotecan for chemoembolization of refractory liver metastases from colorectal cancer

Date

09 Sep 2017

Session

Poster display session

Presenters

Giammaria Fiorentini

Citation

Annals of Oncology (2017) 28 (suppl_5): v158-v208. 10.1093/annonc/mdx393

Authors

G. Fiorentini1, D. Sarti1, R. Carandina2, M. Nardella3, L. Mulazzani4, A. Felicioli4, D. Barnes Navarro5, F. Mugnos Gomez6, O. Zoras7, C. Aliberti2

Author affiliations

  • 1 Oncology-hematology, Ospedale San Salvatore, 61100 - Pesaro/IT
  • 2 Interventional Radiology, Oncology Institute of Veneto, Institute for the Research and Treatment of Cancer (IRCC),, 35128 - Padova/IT
  • 3 Radiology, Azienda Sanitaria Locale Matera, Madonna delle Grazie Hospital, 75100 - Matera/IT
  • 4 Diagnostics For Images Unit And Interventional Radiology, Ospedale San Salvatore, 61100 - Pesaro/IT
  • 5 Interventional Radiology, Hospital Clínic de Barcelona, 08036 - Barcelona/ES
  • 6 Radiology, Hospital Universitario y Politecnico La Fe, 46026 - Valencia/ES
  • 7 Surgical Oncology, University of Crete, Medical School, GR-74100 - Crete/GR
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Resources

Abstract 3513

Background

Patients with liver metastases from colorectal cancer are in 80% of cases non-indicated for resection. The standard first line treatment of unresectablelivermetastases is systemic chemotherapy, however this method results in progression for 70% of patients. The indicated therapy for refractory patients is the chemoembolization. In this study we monitored tumor response, and adverse events after chemoembolization of colorectal cancer liver metastases with polyethylene glycol embolics loaded with irinotecan. Secondary objectives were to monitor quality of life, time to progression and survival of patients.

Methods

Patients were included in the study if: affected by CRC-LM, who were refractory to systemic chemotherapy, treated with chemoembolization using polythylene glycol embolics, and liver involvement >50%. Tumor response, performance status (PS), tumor marker antigens, and quality of life (QoL) were monitored at 1, 3 and 6 months after chemoembolization. Q oL was assessed with the palliative scale (PSS).

Results

We treated 50 consecutive CRC-LM patients with chemoembolization using polythylene glycol embolics, their tumor response one month after chemoembolization was 28% of complete response (CR), and 48% of partial response (PR), 8% stable disease (SD), and 16% of progression. Tumor response 3 months after chemoembolization was CR 24%, PR 38%, SD 19% and progression disease (PD) 19%. Tumor response 6 months after chemoembolization was CR 18%, PR 44%, SD 21% and progression disease (PD) 18%. QoL was 90% PPS at each time point. Median time to progression was 2,5 months (range 0,8 - 6). Median follow-up was 14 months (0,8-25 range). Chemoembolizations were performed with no complications. Observed side effects (mild or moderate intensity) were: pain in 32% of patients, increase of transaminase levels in 20% fever in 14%, whereas 30% of patients did not complain any adverse event.

Conclusions

Chemoembolization of refractory liver metastases from colorectal cancer with polyethylene glycol embolics loaded with irinotecan was effective in tumor response and resulted in mild toxicity, and good QoL.

Clinical trial identification

NCT01891552

Legal entity responsible for the study

Giammaria Fiorentini

Funding

None

Disclosure

All authors have declared no conflicts of interest.

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