Abstract 4395
Background
In the 1st line therapy of metastatic colorectal cancer(mCRC), SOX+Bevacizumb(Bev) regimen (L-OHP: 130 mg/m2 day 1, Bev: 7.5 mg/kg day 1, S-1: 80, 100, 120 mg*/body days 1–14 repeated every 3 weeks, *According to body surface area, BSA < 1.25 m2, BSA ≥ 1.25 to
Trial design
This trial is an open-label, multi-center, phase 2 study. Before administration of SOX regimen, Ccr is measured. The patients with Ccr >_70, the standard dose will be administered, and in the patients with Ccr 70>_60, the level 1 dose control (decrease) will be performed, and in the patients with Ccr 60>_50, the level 2 dose control will be performed (in the patients
Clinical trial identification
UMIN000015446
Legal entity responsible for the study
Kyoto Katsura Hospital
Funding
None
Disclosure
All authors have declared no conflicts of interest.