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Poster display session

4395 - Phase II study of Ccr-based dose-control of S-1 in the first-line chemotherapy of S-1 /oxaliplatin(SOX)+bevacizumab regimen for advanced colorectal cancer

Date

09 Sep 2017

Session

Poster display session

Presenters

DAI MANAKA

Citation

Annals of Oncology (2017) 28 (suppl_5): v158-v208. 10.1093/annonc/mdx393

Authors

D. MANAKA, R. Nishitai, S. Konishi, T. Ohta, T. Hattori, H. Ann, K. Kawaguchi, Y. Nishikawa, R. Kudo, S. Hamasu

Author affiliations

  • Dept. Of Surgery, Gastrointestinal Center, Kyoto Katsura Hospital, 615-8256 - Kyoto/JP
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Resources

Abstract 4395

Background

In the 1st line therapy of metastatic colorectal cancer(mCRC), SOX+Bevacizumb(Bev) regimen (L-OHP: 130 mg/m2 day 1, Bev: 7.5 mg/kg day 1, S-1: 80, 100, 120 mg*/body days 1–14 repeated every 3 weeks, *According to body surface area, BSA < 1.25 m2, BSA ≥ 1.25 to 

Trial design

This trial is an open-label, multi-center, phase 2 study. Before administration of SOX regimen, Ccr is measured. The patients with Ccr >_70, the standard dose will be administered, and in the patients with Ccr 70>_60, the level 1 dose control (decrease) will be performed, and in the patients with Ccr 60>_50, the level 2 dose control will be performed (in the patients

Clinical trial identification

UMIN000015446

Legal entity responsible for the study

Kyoto Katsura Hospital

Funding

None

Disclosure

All authors have declared no conflicts of interest.

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