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Poster display session

3296 - PSA kinetics impact on CT-PET PSMA uptake in prostate cancer

Date

10 Sep 2017

Session

Poster display session

Presenters

Avishay Sella

Citation

Annals of Oncology (2017) 28 (suppl_5): v269-v294. 10.1093/annonc/mdx370

Authors

A. Sella1, S. Kovel2, T. Sella3

Author affiliations

  • 1 Zerifin, Asaf Harofe Medial center, 73100 - Beer Jacob/IL
  • 2 Oncology, Asaf Harofe Medial center, 73100 - Beer Jacob/IL
  • 3 Oncology, Cheba Medical Center, Ramat Gan/IL
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Resources

Abstract 3296

Background

CT-PET PSMA has recently been approved to more accurately detect the extent of prostate cancer. Here we examined PSA level and kinetics (PSA doubling time-PSADT) as a predictor of positive up-take in patients evaluated for suspected recurrent disease.

Methods

We retrospectively collected data on 99 patients evaluated by CT-PET PSMA. Mann-Whitney U test and student's T Test (SPSS 20) were applied to test for differences in median in PSA and PSADT level, Pearson test was used for correlation analysis. PSADT was calculated by Memorial Sloan Kettering Cancer Center calculator of 3 recent levels.

Results

Ninety nine patients underwent CT-PET PSMA. Their median age was 71 (52-94) years. Uptake was detected in 84 (84.8%) patients; 51 (51.5%) patients with metastatic disease (lymph nodes, bones, visceral) and 33 (33.3%) patients with only localized disease (prostate, prostatic bed after prostatectomy). Median Gleason 8 (6-10), median PSA 4.66 (0.12-272) ng/ml. CT-PET was positive in 57.1%, 88.9% and 96.8% of patients with PSA levels of ≤ 1, >1-2 and >2 ng/ml, respectively, and 91.7%, 90.5% and 81.8% of patients with PSADT ≤2, >2-6 and > 6 months, respectively. Only median PSA levels were significantly associated with any uptake: 5.90 ± 35.71 vs. 0.35 ± 4.18 ng/ml, p 

Conclusions

The decision to perform CT-PET PSMA in prostate cancer patients suspected to have recurrent or metastatic disease should be based on PSA levels. PSADT is a significant marker for positive metastatic CT-PET PSMA uptake.

Clinical trial identification

Legal entity responsible for the study

Avishay Sella

Funding

None

Disclosure

All authors have declared no conflicts of interest.

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