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Poster display session

2930 - PD-L1 expression in resected colorectal adenocarcinomas is associated with micrometastais

Date

09 Sep 2017

Session

Poster display session

Presenters

Keon Uk Park

Citation

Annals of Oncology (2017) 28 (suppl_5): v158-v208. 10.1093/annonc/mdx393

Authors

K.U. Park1, I. Hwang2, H. Ryoo3, M.H. Heo1

Author affiliations

  • 1 Department Of Internal Medicine, Keimyung University Dongsan Medical Center, 41931 - Daegu/KR
  • 2 Department Of Pathology, Keimyung University Dongsan Medical Center, 41931 - Daegu/KR
  • 3 Department Of Internal Medicine, Catholic University of Daegu School of Medicine, Daegu/KR
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Resources

Abstract 2930

Background

Programmed cell death 1 (PD-1) and its ligand (PD-L1) are key suppressors of the cytotoxic immune response. PD-L1 expression on tumor cells may be induced by the immune microenvironment, resulting in immune escape, and an adverse prognosis in many malignancies. In colorectal carcinoma the response to PD-1/PD-L1 inhibition is correlated with microsatellite instability. However, little is known about the clinicopathologic, molecular, and prognostic characteristics of colorectal carcinoma with PD-L1 expression. In surgically resected colorectal adenocarcinoma, micrometastasis should be crucial for recurrence, and micrometastasis may be related to PD-L1. The aim of this study is to assess the PD-L1 expression and its association with clinicopathologic manifestations.

Methods

PD-L1 expression was evaluated in 176 resected colorectal adenocarcinomas using tissue microarrays. Immunohistochemical staining was performed to evaluate the expression of PD-L1. The relationship of clinicopathologic manifestations and PD-L1 expression in colorectal cancer were evaluated by chi-squared test, Kaplan-Meier survival and Cox regression test.

Results

High PD-L1 expression was present in 52.8% colorectal adenocarcinoma and was not related pathologic T or N stage. High PD-L1 expression was associated with decreased recurrence rate (p 

Conclusions

High PD-L1 expression is an independent prognostic factor, such as pathologic stage in colorectal adenocarcinoma. PD-L1 expression is independent prognostic factor, relating immune response to micrometastasis and immune suppression by PD-L1 may not be effective in micrometastasis of colorectal adenocarcinoma.

Clinical trial identification

Legal entity responsible for the study

None

Funding

None

Disclosure

All authors have declared no conflicts of interest.

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