Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Poster display session

5310 - PANOVA-3: A phase 3 study of TTFields with gemcitabine and nab-paclitaxel for front-line treatment of locally-advanced pancreatic adenocarcinoma (LAPC)

Date

09 Sep 2017

Session

Poster display session

Presenters

Ori Farber

Citation

Annals of Oncology (2017) 28 (suppl_5): v209-v268. 10.1093/annonc/mdx369

Authors

O. Farber1, U. Weinberg1, Z. Bomzon2, M. Giladi3, E.D. Kirson4

Author affiliations

  • 1 Clincal Development, Novocure, 6039 - Luzern/CH
  • 2 Scientific Affairs, Novocure, Haifa/IL
  • 3 Preclinical, Novocure, Haifa/IL
  • 4 R&d, Novocure, Haifa/IL
More

Resources

Abstract 5310

Background

TTFields are a non-invasive, regional antimitotic treatment modality, which has been approved for the treatment of glioblastoma by the FDA. TTFields predominantly act by disrupting the formation of the mitotic spindle during metaphase. TTFields were effective in multiple preclinical models of pancreatic cancer. PANOVA was the first trial testing TTFields in pancreatic cancer patients, demonstrating their safety when combined with gemcitabine and nab-paclitaxel, and preliminary promising efficacy in LAPC. PANOVA-3 is designed to test the efficacy of adding TTFields to the same chemotherapy combination in this disease stage.

Trial design

Approximately 600 patients with unresectable, LAPC (per NCCN guidelines) will be enrolled in this prospective, randomized trial. Patients should have an ECOG score of 0-2 and no prior progression or treatment. Patients will be stratified based on their performance status and geographical region. Gemcitabine and nab-paclitaxel will be administered at standard dose. The NovoTTF-100L (150kHz) system will be used by experimental arm patients for at least 18 hours/day until local disease progression per RECIST Criteria V1.1. Follow up will be performed q8w, including a CT scan of the chest and abdomen. Following local disease progression, patients will be followed monthly for survival. Overall survival will be the primary endpoint and progression-free survival, objective response rate, rate of resectability, quality of life and toxicity will all be secondary endpoints.

Clinical trial identification

Legal entity responsible for the study

Novocure

Funding

Novocure

Disclosure

O. Farber, U. Weinberg, Z. Bomzon, M. Giladi, E.D. Kirson: Employee of Novocure

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences.