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Poster display session

2525 - Oral squamous cell carcinoma cells were sensitized to cetuximab by Eribulin via induction of the mesenchymal-to-epithelial transition.

Date

11 Sep 2017

Session

Poster display session

Presenters

hiroko kitahara

Citation

Annals of Oncology (2017) 28 (suppl_5): v1-v21. 10.1093/annonc/mdx361

Authors

H. kitahara, M. HIRAI, S. Kawashiri, H. Nakamura

Author affiliations

  • Oral And Maxillofacial Surgery, Kanazawa University Graduate School of Medical Science, 920-8641 - Kanazawa/JP
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Resources

Abstract 2525

Background

Inhibition of EGFR signalling has emerged as a new treatment strategy for oral squamous cell carcinoma (OSCC). Previously, we found that loss of EGFR expression in OSCC was associated with EMT, and might have functional implications with regard to resistance to cetuximab, a monoclonal anti-EGFR antibody. Eribulin (a microtubule inhibitor) reportedly renders breast cancer less aggressive, and less likely to metastasise, by triggering the mesenchymal-to-epithelial (MET) transition. Here, we evaluated whether eribulin-induced MET was associated with re-sensitization of resistant OSCC cell lines to cetuximab.

Methods

In vitro antiproliferative activities were determined in three human OSCC lines (OSC-20, OSC-19 and HOC313) treated with eribulin. These three human OSCC represented different EMT/MET states.

Results

Interestingly, HOC313 cells (mesenchymal phenotype) were highly sensitive to eribulin in comparison with other cell lines, and significantly enhanced the anti-proliferative effect of cetuximab in response to the drug. Eribulin also underwent a MET-associated gene switch that resulted in high EGFR expression in HOC313 cells, and abrogated a TGF-β-induced EMT gene expression signature.

Conclusions

Eribulin-dependent sensitization of OSCC to cetuximab is likely due to induction of MET. Combination therapies based on eribulin and cetuximab have potential as a novel treatment regimen in OSCC.

Clinical trial identification

Legal entity responsible for the study

Kanazawa University

Funding

None

Disclosure

All authors have declared no conflicts of interest.

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