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Poster display session

4596 - Oncotype DX score, menopausal status and body mass index

Date

11 Sep 2017

Session

Poster display session

Presenters

Sarah Picardo

Citation

Annals of Oncology (2017) 28 (suppl_5): v43-v67. 10.1093/annonc/mdx362

Authors

S. Picardo1, J. Sui2, M. Greally3, B. Woulfe4, L. Prior5, L. Corrigan6, C. O'Leary6, W. Mullally2, J. Walshe7, J. McCaffrey8, M. O'Connor6, D. O'Mahony2, L. Coate9, R. Gupta10, S. O'Reilly11

Author affiliations

  • 1 Department Of Medical Oncology, University Hospital Limerick, Co. - Limerick/IE
  • 2 Department Of Medical Oncology, Cork University Hospital, Cork/IE
  • 3 Department Of Medical Oncology, Mater Misericordiae University Hospital, Dublin/IE
  • 4 Department Of Medical Oncology, University Hospital Limerick, Limerick/IE
  • 5 Department Of Medical Oncology, St Vincent's University Hospital, Dublin/IE
  • 6 Medical Oncology, University Hospital Waterford, Waterford/IE
  • 7 Department Of Medical Oncology, St Vincents University Hospital, 4 - Dublin/IE
  • 8 Medical Oncology, Mater Misericordiae University Hospital, University College Dublin (UCD) & Cancer Trials Ireland, 7 - Dublin/IE
  • 9 Department Of Medical Oncology, University Hospital Limerick, Mid Western Cancer Centre,, County Limerick - Limerick/IE
  • 10 Department Of Medical Oncology, Mid-Western Regional Hospital, 4048 - Limerick/IE
  • 11 Medical Oncology, Cork University Hospital, Cork/IE
More

Resources

Abstract 4596

Background

The Oncotype DX assay uses expression of 21 genes to predict the risk of distant disease recurrence in patients with oestrogen receptor positive Her2 negative breast cancer. It has been demonstrated that increased intra-tumoural inflammation is associated with higher Oncotype score. An inflammatory milieu within the breast is associated with more aggressive histological cancer subtypes, and also with obesity, which is recognised as a risk factor for breast cancer. The association between obesity and breast cancer is higher in post-menopausal than pre-menopausal women. Therefore this study aimed to investigate whether there is a correlation between Oncotype score, menopausal status and obesity.

Methods

All patients with Oncotype assays performed between 2008 and 2016 in several centres in Ireland were identified. Data was retrospectively collected on weight, body mass index (BMI), menopausal status and Oncotype scores, including oestrogen (ER) and progesterone (PR) scores. Statistical analysis assessed correlation between Oncotype scores and these factors.

Results

Analysis was performed on 269 patients from a single centre with early stage breast cancer. Median age was 53.4 years and the majority of patients (58%) were post-menopausal at diagnosis. Patients who had a BMI less than 25 (normal weight) had significantly lower Oncotype score than those with BMI greater than 25 (overweight/obese) (p 

Conclusions

Oncotype score is higher in overweight patients with early stage node-negative breast cancer. This difference appears to be independent of ER and PR scores and correlates with menopausal status. This retrospective study is the first to suggest that the body mass index and menopausal status of patients with early stage breast cancer may influence the Oncotype DX recurrence score and analysis of a further cohort of patients is ongoing.

Clinical trial identification

Legal entity responsible for the study

Seamus O’Reilly

Funding

None

Disclosure

All authors have declared no conflicts of interest.

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