Myeloid Derived Suppressor cells (MDSC) are immune suppressive cells associated with poor survival in several cancers. In this study, we investigated their impact on spontaneous tumor antigen specific Th1 responses in Non-Small Cell Lung Cancer (NSCLC).
Monocytic MDSC (M-MDSC) (Lin-HL-DR-/loCD11b+CD14+CD33+) were measured in peripheral blood of 122 NSCLC patients and 34 healthy donors by flow cytometry. The presence of spontaneous anti-tumor Th1 response was measured by IFN-ɣ ELISPOT assay using mixture of peptides derived from lung cancer-associated tumor antigens such as telomerase, NY-ESO1 and Wilms Tumor-1. Patients’ samples were collected at baseline before any treatment.
Higher percentage of circulating M-MDSC was found in NSCLC patients compared to healthy subjects (mean: 3.9±0.4% vs 1.5±0.4%, p
Our results show that high levels of circulating M-MDSC is associated with a decrease of pre-existing antitumor T cell response. The level of M-MDSC combined with antitumor T cell responses could predict distinct clinical outcome. Thus, monitoring M-MDSC in blood could be used as relevant immune biomarker in NSCLC.
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All authors have declared no conflicts of interest.