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Poster display session

3378 - Monitoring of contamination with cytostatics in pharmacies and hospitals in the Czech Republic

Date

10 Sep 2017

Session

Poster display session

Presenters

Sarka Kozakova

Citation

Annals of Oncology (2017) 28 (suppl_5): v511-v520. 10.1093/annonc/mdx385

Authors

S. Kozakova

Author affiliations

  • Pharmacy, Masaryk Memorial Cancer Institute, 65653 - Brno/CZ
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Resources

Abstract 3378

Background

Monitoring of contamination with cytostatics was introduced in practice in the Czech Republic by CYTO project managed by the pharmacy of Masaryk Memorial Cancer Institute (MMI) in years 2006-2010. The number of prescriptions of cytostatic drugs increased within the Czech Republic from 23000 bags and syringes in 2010 up to 38000 in 2015. So as to set up standards for the protection of healthcare professionals, it is necessary to monitor contamination regularly at all work sites engaged in compounding or administration - both in the pharmacy (Pharm) and at the hospital departments (HD)/stationaries (S). We have introduced the monitoring of cyclophosphamide (CP) and Pt cytostatics (Pt) to routine practice in 2007. In 2015, there was also implemented monitoring of 5-fluorouracil (FU). These drugs belong to the most frequently used cytostatics in MMI (49.0% of compounded units).

Methods

The samples for detection of contamination of surfaces were collected with a nonwoven swab. CP and FU were assessed with HPLC with TQ-S MS, with limits of detection 1.1pg.cm−2 for CP und 7 pg.cm−2 for FU. Pt cytostatics were analyzed by MS with inductively coupled plasma proving LOD 0.7 pg.cm−2.

Results

Maximal levels of FU detected on floors were: 775 pg.cm−2 at HD, 564 pg.cm−2 in P, at compounding units and 25 pg.cm−2 in P, in storage rooms. Similarly, maximal detected levels of CP on floors were found at the HD: 3244 pg.cm−2, 638 pg.cm−2 in the P, compounding units and 235 pg.cm−2 in P, in the storage rooms. Maximal detected levels of Pt on floors was again found in the HD, with levels of 5390 pg.cm−2, then 84 pg.cm−2 in P, compounding units, and 57 pg.cm−2 in P, in the storage rooms.

Conclusions

According to our findings, hospital pharmacists are able to decrease the contamination on their workplaces. On the other hand, improvement is needed at the hospital departments and stationaries, where hospital pharmacists may co-operate on setting the safety standards.

Clinical trial identification

Legal entity responsible for the study

Masaryk Memorial Cancer Institute

Funding

Masaryk Memorial Cancer Institute

Disclosure

All authors have declared no conflicts of interest.

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