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Poster display session

3410 - Modified Glasgow prognostic score, prognostic nutritional index and ECOG score could be new prognostic factors for survival in metastatic gastric cancer.

Date

09 Sep 2017

Session

Poster display session

Presenters

Bülent Demirelli

Citation

Annals of Oncology (2017) 28 (suppl_5): v209-v268. 10.1093/annonc/mdx369

Authors

B. Demirelli1, N. Babacan2, S. Koca2, B.N. Uzun3, Ö. Ercelep2, M.A. Ozturk2, S. Kaya2, E.T. Simsek2, S. Khalil2, R. Hasanov2, O. Alan2, T.A. Telli2, M.E. Arıbal3, F. Dane2, F. Yumuk2

Author affiliations

  • 1 Internal Medicine, Marmara University Hospital, 34600 - Istanbul/TR
  • 2 Medical Oncology, Marmara University Hospital, 34600 - Istanbul/TR
  • 3 Radiology, Marmara University Hospital, 34600 - Istanbul/TR
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Resources

Abstract 3410

Background

Metastatic gastric carcinoma (MGC) patients usually present with cachexia and sarcopenia. We aimed to analyze the prognostic values of the sarcopenia index (SI), cachexia index (CI) and inflammatory indexes (advanced lung cancer inflammation index [ALI], modified Glasgow Prognostic Score [mGPS], prognostic index [PI], prognostic nutritional index [PNI] and neutrophil-to-lymphocyte ratio [NLR]) on MGC at presentation.

Methods

A retrospective study was performed in 87 patients with MGC. SI, CI, PI, PNI, ALI, mGPS and NLR was measured and calculated appropriately. Due to lack of studies from our country, SI cutoff value has been obtained by using both western (EGWSOP) and eastern (Harada Y, et al) sources separately. Statistical analysis has been done by SPSS.

Results

Median follow-up time was 9 months (range 1-64) and 78 patients died during follow-up. Fiftynine patients were male (63%) and median age was 62 (23-88). According to univariate analysis these factors had significant negative impact on general survival (GS): increased leukocyte (p = 0,003) and neutrophile (p 

Conclusions

On our study; mGPS, PNI and ECOG score were independent indicators for shorter survival. mGPS and PNI, which can be calculated by using only CRP, albumin levels and complete blood counts, might be inexpensive, practical and beneficial in routine clinical practice.

Clinical trial identification

Legal entity responsible for the study

Marmara University Pendik Treatment & Research Hospital, Medical Oncology Department

Funding

None

Disclosure

All authors have declared no conflicts of interest.

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