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Poster display session

3277 - Long Term Survival in Patients Responding to an Anti-PD-1/PD-L1 Therapy and Disease Outcome Upon Treatment Discontinuation

Date

10 Sep 2017

Session

Poster display session

Presenters

Marie-Léa Gauci

Citation

Annals of Oncology (2017) 28 (suppl_5): v403-v427. 10.1093/annonc/mdx376

Authors

M. Gauci1, E. Lanoy2, S. Champiat3, J. Michot1, A. Varga1, R. Bahleda1, E. Angevin1, A. Gazzah1, L. Verlingue1, F. Bigot1, S. Aspeslagh1, E. Castanon1, C. Baldini1, S. Postel-Vinay1, C. Massard1, A. Hollebecque1, J. Soria1, A. Marabelle1

Author affiliations

  • 1 Drug Development Department (ditep), Gustave Roussy, 94805 - Villejuif/FR
  • 2 Biostatistiques Et Epidémiologie, Institut Gustave Roussy, 94800 - Villejuif/FR
  • 3 Inserm U981, Gustave Roussy, 94805 - Villejuif/FR
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Resources

Abstract 3277

Background

The long-term outcome of cancer patients responding to an anti-PD-1/PD-L1 immunotherapy (IT) remains unknown. This study aimed to describe the long-term survival of patients responding to anti-PD-1/PD-L1 monotherapy across multiple cancer types.

Methods

306 patients treated with an anti-PD-1 or PD-L1 monotherapy in a phase 1 trial at Gustave Roussy were retrospectively analyzed over a period of 5 years. Major inclusion criteria were: at least 18 years-old, performance status 0-1, at least 1 infusion, evaluation by RECIST 1:1 and/or irRC. Multiple myeloma patients were excluded as they do not respond to anti-PD-1 monotherapy. All other cancer types (n = 19) were included.

Results

The overall objective response rate within this cohort of 262 patients was 29% (n = 76; 77% being evaluated by irRC). The median PFS of responders was 22 months and the median OS was not reached. The OS of patients responding to IT at 3 years was 76% and at 5 years was 63%. Long responders (patients with enough follow up to have tumor responses lasting more than 2 years) represented 11.8% of the cohort (31 patients). No death occurred in the 21 complete responders over this long term follow up. The median duration of response was not reached. Out of the 33 patients who disontinued immunotherapy, 9 patients showed a disease relapse (median response duration after treatment discontinuation: 6 months). Clinical and biological factors associated with response, long term survival, and secondary refractory disease will be reported at the ESMO meeting.

Conclusions

This study shows that, across cancer types, patients with objective tumor responses under anti-PD-1/PD-L1 immunotherapy have a high level of overall survival. Best survivals are seen with complete responses (no deaths in our cohort). Complete response rate might be a good short term surrogate marker for overall survival benefits. Clinical trials aiming at putting patients with partial responses under immunotherapy into complete responses should be assessed in a near future.

Clinical trial identification

N/A

Legal entity responsible for the study

Gustave Roussy

Funding

None

Disclosure

All authors have declared no conflicts of interest.

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