Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Poster display session

3173 - Incidence and survival of secondary malignances (SM) in oropharingeal squamous cell carcinoma (OPSCC): a homogeneous single report institution

Date

10 Sep 2017

Session

Poster display session

Presenters

Martina Napolitano

Citation

Annals of Oncology (2017) 28 (suppl_5): v372-v394. 10.1093/annonc/mdx374

Authors

M. Napolitano1, F. Bertolini1, E. D'Angelo2, A. Spallanzani1, S. Tassi3, B. Meduri2, S. Bettelli4, R. Depenni1, A. Ghidini3, F. Lohr2, L. Presutti3, S. Cascinu1

Author affiliations

  • 1 Department Of Oncology, Modena University Hospital, 41124 - Modena/IT
  • 2 Radiotherapy Service, Modena University Hospital, Modena/IT
  • 3 Ent Surgery Dept, Modena University Hospital, Modena/IT
  • 4 Molecular Biology Lab, Modena University Hospital, Modena/IT
More

Resources

Abstract 3173

Background

SM in HNSCC patients (pts) are common, due to the presence of risk factors (smoking habit or alcohol abuse). Aim of this report is to evaluate the incidence and characteristics of SM in a series of OPSCC.

Methods

We retrospectively reviewed clinical data of 266 pts with OPSCC seen at Modena University Hospital between 2006 and 2016. We recorded data from a web platform in which every pt has a personal form filled with clinical information. In particular, we analyzed the rate of SM and described clinical and survival data.

Results

SM was diagnosed in 37 pts (13,9%): 15 NSCLC (5% on all; 40,5% of SM); 7 HNSCC (18,9%), 8 GI (21,6%), 2 prostate (5,4%), 2 thyroid cancer (5,4%), 2 hematologic malignancy (5,4%) and 1 melanoma (2,7%). Clinical features at diagnosis for OPSCC: 30 (81%) male, 7 (19%) female; median age 68 years (range 37-90). Twenty-five pts (67,6%) were current/former smokers, 26 (70,3%) HPV-positive; stage at diagnosis was I-II in 5 (13,5%) and III-IV in 32 pts (86,5%). Eleven pts developed SM 

Conclusions

In our retrospective series, we confirmed that secondary lung cancer was the most frequent SM; it was diagnosed at earlier stage, because these pts underwent a periodical follow-up for their previous OPSCC with a chest X-ray/CT. Smokers may benefit from a more intensive follow-up for a higher risk of smoking related SM (lung, HNSCC). Survival is more influenced by the occurrence of SM than by OPSCC. All these considerations should be applied to a larger series.

Clinical trial identification

Legal entity responsible for the study

Modena University Hospital

Funding

None

Disclosure

All authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences.