SM in HNSCC patients (pts) are common, due to the presence of risk factors (smoking habit or alcohol abuse). Aim of this report is to evaluate the incidence and characteristics of SM in a series of OPSCC.
We retrospectively reviewed clinical data of 266 pts with OPSCC seen at Modena University Hospital between 2006 and 2016. We recorded data from a web platform in which every pt has a personal form filled with clinical information. In particular, we analyzed the rate of SM and described clinical and survival data.
SM was diagnosed in 37 pts (13,9%): 15 NSCLC (5% on all; 40,5% of SM); 7 HNSCC (18,9%), 8 GI (21,6%), 2 prostate (5,4%), 2 thyroid cancer (5,4%), 2 hematologic malignancy (5,4%) and 1 melanoma (2,7%). Clinical features at diagnosis for OPSCC: 30 (81%) male, 7 (19%) female; median age 68 years (range 37-90). Twenty-five pts (67,6%) were current/former smokers, 26 (70,3%) HPV-positive; stage at diagnosis was I-II in 5 (13,5%) and III-IV in 32 pts (86,5%). Eleven pts developed SM
In our retrospective series, we confirmed that secondary lung cancer was the most frequent SM; it was diagnosed at earlier stage, because these pts underwent a periodical follow-up for their previous OPSCC with a chest X-ray/CT. Smokers may benefit from a more intensive follow-up for a higher risk of smoking related SM (lung, HNSCC). Survival is more influenced by the occurrence of SM than by OPSCC. All these considerations should be applied to a larger series.
Clinical trial identification
Legal entity responsible for the study
Modena University Hospital
All authors have declared no conflicts of interest.