Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Poster display session

1858 - Impact of resistance exercise on metabolic syndrome (MetS) parameters in men receiving androgen deprivation therapy (ADT) for prostate cancer

Date

10 Sep 2017

Session

Poster display session

Presenters

Tanya Dorff

Citation

Annals of Oncology (2017) 28 (suppl_5): v543-v567. 10.1093/annonc/mdx388

Authors

T. Dorff1, M. Gross1, D.I. Quinn1, J. Pinski1, T. Schroeder2, S. Groshen3, C. Dieli-Conwright2, J. Kiwata2

Author affiliations

  • 1 Keck School Of Medicine, Division Of Medical Oncology, University of Southern California Norris Comprehensive Cancer Center, 90033 - Los Angeles/US
  • 2 Division Of Biokinesiology And Physical Therapy, University of Southern California, Keck School of Medicine, Los Angeles/US
  • 3 Preventive Medicine-biostatistics, University of Southern California, Keck School of Medicine, Los Angeles/US
More

Resources

Abstract 1858

Background

Cardiovascular disease is the leading cause of death in men with prostate cancer. ADT is effective treatment, but can adversely impact MetS components, which may contribute to excess cardiac risk. We tested whether a resistance exercise program, designed to increase skeletal muscle mass during ADT, could offset adverse changes.

Methods

Prostate cancer patients on ADT were randomized to exercise (EX) or no exercise (noEX). EX was supervised, periodized resistance training followed by stretching 3x/week for 12 weeks, 45 min/session. noEX did home-based stretching 3x/week. Baseline and post-intervention measurements included weight, waist circumference (wCirc), lean body mass, lipids, insulin, glucose. Mean differences in changes were compared with intent-to-treat linear regression models adjusted for baseline values. Cohen’s D effect sizes were calculated for these pilot data to estimate effects for a fully powered trial.

Results

Thirty-two men (EX n = 13, noEX n = 19) completed the protocol. Age (mean± SD) was 67.3 ± 8.7 yr (range 52 - 84). Mean duration ADT was 14.4 ± 13.4 months (range 3 – 57). EX patients had higher baseline BMI with 63% >25 kg/m2 compared to 25% in the NoEX group, p = 0.024. wCirc decreased significantly (p = 0.032) in EX (-1.18 cm 95%CI [-3.3, -1.0] cm) compared to NoEX (+1.97 cm [0.2, 3.7]). Lean mass increased and body fat decreased in EX compared to NoEX. Moderate effect sizes (D = 0.2-0.5) were seen between groups for other parameters (see Table).rnTable:

1575P

rnrnrnrnrnrnrnrnrnrnrnrnrnrnrnrnrnrnrnrnrnrnrnrnrnrnrnrnrnrnrnrnrnrnrnrnrnrnrnrnrnrnrnrnrnrnrnrnrnrnrnrnrnrnrnrnrnrnrnrnrnrn
Baseline meanWeek 12 meanMean change [95% CI]pD
wCirc (cm) EX NoEX106.8 97.9105.9 99.6−1.18 [-3.3, -1.0] 1.97 [0.2, 3.7]0.0320.8
Lean Body Mass (kg) EX NoEX48.5 kg 51.5 kg43.2 kg 48.6 kg1.07 [0.35, 1.79] 0.09 [-0.5, 0.68]0.0470.8
Body Fat EX NoEX36.8% 33.9%35.9% 34.5%−0.9 [-1.78, -0.01] 0.49 [-0.24, 1.22]0.0221
Diastolic BP (mmHg) EX NoEX76.9 79.075.4 79−1.91 [-6.3, 2.5] 0.31 [-3.3, 4.0]0.4370.3
HDL-C (mg/dL) EX NoEX46.5 61.349.0 61.53.83 [-1.9, 9.6] -0.32 [-4.8, 4.1]0.2700.4
HOMA-IR EX NoEX2.56 1.341.42 1.82−0.63 [-1.9, 0.6] -0.01 [-1.0, 1.0]0.4330.3
rn

Conclusions

Supervised resistance exercise for 12 weeks improves wCirc and body composition in men receiving ADT for prostate cancer with moderate effect on other MetS parameters.

Clinical trial identification

NCT01909440

Legal entity responsible for the study

University of Southern California, Keck School of Medicine

Funding

National Strength and Conditioning Association, California State University Chancellor's Doctoral Incentive Program

Disclosure

All authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences.