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Poster display session

2591 - Head and neck cancer (HNC) and synchronic lung cancer: impact of the lung cancer on the management and prognosis of these patients. Data from the SYNCHRON GFPC 15-04 Study

Date

10 Sep 2017

Session

Poster display session

Presenters

Nicolas Paleiron

Citation

Annals of Oncology (2017) 28 (suppl_5): v372-v394. 10.1093/annonc/mdx374

Authors

N. Paleiron1, L. SARAMON2, G. Robinet3, R. Gervais4, P. Fournel5, H. Le Caer6, H. Berard7, G. Valette2, R. Marianowski2, C. Chouaid8

Author affiliations

  • 1 Pneumology, HIA Brest, 29200 - Brest/FR
  • 2 Orl, CHU Brest Morvan, 29200 - Brest/FR
  • 3 Pneumologie, CHU Brest Morvan, 29200 - Brest/FR
  • 4 Oncologie, Centre Francois Baclesse, 14076 - Caen/FR
  • 5 Pneumologie, Institute de Cancerologie de la Loire, 42271 - St. Priest en Jarez/FR
  • 6 Pneumologie, Hôpital de St Brieuc, St brieuc/FR
  • 7 Pneumologie, Hôpital d'Instruction des Armées (HIA) Ste Anne, 83000 - Toulon/FR
  • 8 Pneumologie, CHI créteil, creteil/FR
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Resources

Abstract 2591

Background

Management of synchronous head and neck and lung cancer is almost difficult. The aim of this observational study was to describe the impact of the lung cancer on the management and prognosis of HNC.

Methods

Inclusion criteria were: consecutive patients diagnosed between January 2011 and December 2015 in 19 French centers with HNC and synchronous lung cancer (all stages). We describe: clinical characteristics, management and outcomes. Patient characteristics and treatment information was analyzed descriptively. Kaplan-Meier estimation was used to assess median overall survival.

Results

The study included 132 patients: men: 83%; 63,7 years old, current smokers: 59,8%; performans status: 0 and 1 for 22% and 66% of the patients respectively; high rate of comorbidities: cardiovascular: 63%, COPD: 33%. Main histology for HNC was squamous: 98%, (in oral cavity: 24%, oropharyngeal: 26%, hypo-pharyngeal: 22% and laryngeal: 28%) T classification was T1, T2, T3 and T4 in 16%, 24%, 28% and 18% of cases respectively, and N classification was N0, N1, N2, N3, for 36%, 18%, 20% and 8% of cases respectively. The main treatment was surgery, 37,1%, and chemo-radiotherapy, 35,6%. The diagnosis of lung cancer impacts the HNC management in 38% of the cases. Median delay between HNC and first day treatment was 54 days. HNC progressive free survival rate was 68% at 2 years. Lung cancers were mostly localized (stages I: 46%, stages II: 10%), squamous: 39%, or adeno-carcinomas: 39%. Main treatments were surgery: 29%, mainly lobectomy, radiotherapy: 13%, radio-chemotherapy: 14% and chemotherapy alone: 35%. Seven patients didn’t receive active treatment. Median delay of treatment was 82,3 days. Lung cancer progressive free survival rate was 35% at 2 years. OS was 40% at 2 years, better for stage I - II lung cancers (55%).

Conclusions

Synchronous lung cancer at HNC diagnosis significantly impacts the management and outcomes of HNC. Specific recommendations and multidisciplinary approach should be elaborate to improve the management of these patients.

Clinical trial identification

Legal entity responsible for the study

Groupe Français de Pneumo-cancérologie

Funding

Boringer Pierre Fabre

Disclosure

All authors have declared no conflicts of interest.

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