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Poster display session

3711 - HER2 overexpression and amplification in patients with colorectal cancer (HOLIC): A large-scale retrospective study in Chinese population

Date

09 Sep 2017

Session

Poster display session

Presenters

Shujuan NI

Citation

Annals of Oncology (2017) 28 (suppl_5): v158-v208. 10.1093/annonc/mdx393

Authors

S. NI1, J. Peng2, D. Huang1, H. Sun1, L. Wang1, C. Tan1, J. Cai2, W. Sheng1

Author affiliations

  • 1 Pathology, Fudan University Shanghai Cancer Center, 200032 - Shanghai/CN
  • 2 Colorectal Surgery, Fudan University Shanghai Cancer Center, 200032 - Shanghai/CN
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Resources

Abstract 3711

Background

HER2 overexpression or amplification may be a potentially predictive factor for anti-HER2 response and anti-EGFR resistance in colorectal cancer (CRC). However, the prevalence of HER2 positivity in CRC patients and its correlation with clinicopathologic features are not clear.

Methods

HER2 and MMR protein expression were tested by immunohistochemistry (IHC) in formalin-fixed, paraffin-embedded samples from 4,913 consecutive CRC patients treated with surgical resection during 2011-2014 in our institution. Dual color silver-enhanced in situ hybridization (DISH) was performed in all IHC 3+/2+ cases. The scoring criteria of HER2 status in gastric cancer was used. RAS/BRAF mutation status was assessed by Sanger DNA sequencing.

Results

HER2 positivity was found in 160/4,913 (3.3%) cases, including 68 cases (42.5%) with IHC 3+ and 92 cases (57.5%) with IHC 2+/DISH+. HER2 positivity was more common in younger patients (

Conclusions

To our knowledge, this is the largest study of HER2 status in Asian patients with CRC. HER2 positivity occurred in a small number of patients with CRC, related to unfavorable prognostic factors, more common in younger patients and rare in MMR deficiency cases. Compared with previous results in western population, the RAS/BRAF mutation rate of HER2 positive Chinese CRC patients seems much higher. The further study regarding molecular information of these HER2 positive CRC patients is ongoing.

Clinical trial identification

Legal entity responsible for the study

Fudan University Shanghai Cancer Center

Funding

None

Disclosure

All authors have declared no conflicts of interest.

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