Clinical outcomes for pts with HER2+ MBC may differ by age, potentially influenced by differences in treatment regimens administered to older vs younger pts. Systematic Therapies for HER2+ Metastatic Breast Cancer Study (SystHERs) captures real-world treatment patterns and outcomes in pts with HER2+ MBC. Here, we examine baseline characteristics, first-line treatments, and breast cancer–specific survival (BCSS) by age.
SystHERs is a fully enrolled (Jun 2012–Jun 2016), ongoing, US-based, observational study. Pts were ≥18 years old and had HER2+ MBC diagnosed within 6 months of enrollment. Pts were grouped by age at MBC diagnosis (
As of Feb 10, 2017, of 978 eligible pts, 287 were
In this preliminary real-world analysis of pts with HER2+ MBC, pertuzumab (P) + trastuzumab (H) was more commonly used than H without P across all age groups. Pts
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M. Jahanzeb: Consulting fees from Roche. Data and Safety Monitoring Board for Puma. D. Tripathy: Consulting fees from Puma Biotech, NEKTAR Pharma, Novartis. Contracted research paid to institution from Novartis. S.A. Hurvitz: Research funding from Amgen, Bayer, Boehringer Ingleheim, Genentech, GSK, Pfizer, Roche, Biomarin, Merrimack, PUMA, Dignitana, Medication. Research and travel from Lilly, Novartis, OBI Pharma. J. O\'Shaughnessy: Consulting fees from Genentech. G. Mason: Advisory Board: Avon Foundation for Women Scientific. D.A. Yardley: Fees for services from Novartis and Genentech. Contracted research paid to institution from Genentech and Novartis. A. Brufsky: Consulting fees from Roche. H.S. Rugo: Fees for services from Genomic Health. contracted research paid to institution from Genentech, Pfizer, Novartis, Lilly, OBI Pharma, GTX, Macrogenics, Merck. M. Cobleigh: Royalties and Receipt of IP rights from Genomic Health. Consulting fees from Genentech/Roche and GSK. Contracted research from Genentech/Roche, Merrimack, Macrogenics, NRG foundation. S.M. Swain: Consulting fees from Genentech/Roche, Novartis, and Pieris. Contracted research paid to institution from Genentech/Roche, Pfizer, Merrimack, and Lilly. L. Chu, V. Antao, B. Yoo: Employment at Genentech. Stock ownership in Roche. P.A. Kaufman: Consulting fees from Genentech. Contracted research paid to institution from Genentech/Roche.