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Poster display session

5060 - Differences in survival (sv) and clinicopathologic characteristics (cpc) between right and left-sided colorrectal cancer (CRC), a CARESS-CCR Group Study.

Date

09 Sep 2017

Session

Poster display session

Presenters

Julia Alcaide-Garcia

Citation

Annals of Oncology (2017) 28 (suppl_5): v158-v208. 10.1093/annonc/mdx393

Authors

J. Alcaide-Garcia1, I. Zarcos-Pedrinaci1, A. Rueda Domínguez1, F. Rivas-Ruiz2, T. Tellez2, M.M. Morales Suarez-Varela3, E. Briones4, M. Bare5, A. Escobar6, C. Sarasqueta7, N. Fernández de Larrea8, J.M. Quintana9, E. Pérez-Ruiz1, R. Villatoro10, D. Perez10, M. Redondo2

Author affiliations

  • 1 Medical Oncology, Hospital Costa del Sol, Red de Investigación en Servicios de Salud en Enfermedades Crónicas – REDISSEC, 29603 - Marbella/ES
  • 2 Research Unit, Hospital Costa del Sol, Red de Investigación en Servicios de Salud en Enfermedades Crónicas – REDISSEC, 29603 - Marbella/ES
  • 3 Preventive Medicine And Public Health, Food Science, Toxicology And Legal Medicine, Unit of Public Health, Hygiene and Environmental Health, University of Valencia, CIBER-Epidemiology and Public Health (CIBERESP), 46010 - Valencia/ES
  • 4 Public Health Unit, Distrito Sanitario Sevilla, Consorcio de Investigación Biomédica de Epidemiología y Salud Pública, 28070 - Madrid/ES
  • 5 Clinical Epidemiology And Cancer Screening, Corporació Sanitària Parc Taulí,, Red de Investigación en Servicios de Salud en Enfermedades Crónicas – REDISSEC, 29603 - Sabadell/ES
  • 6 Research Unit, Hospital Universitario Basurto, Red de Investigación en Servicios de Salud en Enfermedades Crónicas – REDISSEC, 29603 - Bilbao/ES
  • 7 Research Unit, Donostia University Hospital, Red de Investigación en Servicios de Salud en Enfermedades Crónicas – REDISSEC, 29603 - San Sebastián/ES
  • 8 Area Of Environmental Epidemiology And Cancer, National Epidemiology Centre, Instituto de Salud Carlos III, Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública, CIBERESP), Red de Investigación en Servicios de Salud en Enfermedades Crónicas – REDISS, 29603 - Madrid/ES
  • 9 Research Unit, Hospital Galdakao-Usansolo, Red de Investigación en Servicios de Salud en Enfermedades Crónicas – REDISSEC, 29603 - Galdakao/ES
  • 10 Oncology, Hospital Costa del Sol, Marbella/ES
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Resources

Abstract 5060

Background

Until now, we have managed all CRC patients (pts) in the same way, However, emergent data show that location of primary tumor can have a prognostic and predictive value in metastatic setting. In this study, we analized differences in sv and cpc between right (R) and left-sided (L) CRC.

Methods

This prospective, multicentre observational study was conducted in coordination with 22 public-sector hospitals of Spain. Pts diagnosed with new CRC, stage I-IV and surgically treated, were included. We defined R-CRC as tumors originated in cecum, ascending colon, hepatic flexure or transverse colon, and L in splenic flexure, descending and sigmoid colon or rectum.

Results

Of 2694 recruited pts, 807 (30%) had R and 1887 (70%) L-CRCs. Most of cases were non-metastatic (89.9%), and males (63.5%). Mortality risk was higher for R-CRC and independent of stage (localised vs metastatic), with HR 1.69; 95% IC 1.24-2.29. Pts with R-tumors were slightly older than L, with a higher Body Mass Index (BMI), a greater predominance of women, non-smokers and regular Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) users. At presentation, they stayed asymptomatic, had elevated CA 19.9 or interval CRCs (diagnosed after negative screening test), and needed urgent surgery more frequently. They also showed special histologies, high grade and vascular invasion more often than L. Although differences in N and M staging were not detected, we observed more T1-T2 in L and more T3- T4 in R-tumors.Table:

585P Differences in sv and cpc

R-CRCL-CRCp
Sv 2 years (%, 95% IC)87.110-T219.529.2
T3-T480.167.8

Conclusions

R and L-CRCs are different, and prognosis is better for L-tumors, independently of stage.

Clinical trial identification

Legal entity responsible for the study

CARESS-CCR Study Group

Funding

REDISSEC (RD12/0001/0010), Fondo de Investigaciones Sanitarias (13/0013) and Fondo Europeo de Desarrollo Regional (FEDER).

Disclosure

All authors have declared no conflicts of interest.

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