Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Poster display session

3453 - Diagnostic analysis of patients referred from general practitioner with serious non-organ-specific symptoms and signs of cancer: a retrospective cohort study

Date

10 Sep 2017

Session

Poster display session

Presenters

Barbara Jørgensen

Citation

Annals of Oncology (2017) 28 (suppl_5): v502-v506. 10.1093/annonc/mdx383

Authors

B.M. Jørgensen1, C. Dehlendorff2, C.M.N. Kistorp3, S.E. Bojesen4, J.S. Johansen5, C.L. Feltoft3

Author affiliations

  • 1 Faculty Of Health And Medical Sciences, University of Copenhagen, 2200 - Copenhagen/DK
  • 2 Statistics And Pharmacoepidemiology, Danish Cancer Society Research Center, Danish Cancer Society, 2100 - Copenhagen/DK
  • 3 Internal Medicine, Herlev and Gentofte Hospital, 2730 - Herlev/DK
  • 4 Clinical Biochemistry, Herlev and Gentofte Hospital, 2730 - Herlev/DK
  • 5 Medical Oncology, Herlev and Gentofte Hospital, 2730 - Herlev/DK
More

Resources

Abstract 3453

Background

Recently, a diagnostic fast track for patients with serious non-organ-specific symptoms and signs of cancer was established in Denmark. For patients without cancer diagnosed within the first month, the prognosis is currently unclear.

Methods

A retrospective cohort study of 926 patients referred to Diagnostic Outpatient Clinic (DOC) at Herlev Hospital from April 2012 to December 2013. Baseline clinical parameters were collected from patient records. Time to cancer, death, cancer specific mortality (CSM), and death due to other causes were recorded until May, 2016. 724 patients were identified without cancer one month after examination and divided into 2 sub-cohorts based on the initial assessment: true negatives (TNs; patients diagnosed without cancer at DOC and after 1 month) and false positives (FPs; patients referred from DOC with suspicion of cancer, but without cancer the 1. month). Cumulative incidence of cancer, death, CSM, and death from other causes were estimated by the Aalen-Johansen estimator using 31 days after initial assessment as baseline. Hazard radios (HR) and 95% confidence intervals (CIs) for the initial evaluation were estimated in Cox models with cancer and mortality, respectively, as outcomes.

Results

Clinical characteristics of the 724 patients: median age 65 years (range 17-92); 44% were men; 70% were referred from their general practitioner; 43% were former/current smokers; 18% were former/current alcohol abusers. The median age (p 

Conclusions

Ruling out cancer by investigation at DOC was associated with low risk of subsequent cancer and the NPV was high. The FPs had higher risk of cancer, mortality, and CSM compared to the TNs.

Clinical trial identification

This is not a clinical trial, but a retrospective cohort study.

The project have been approved by the Danish Data Protection Agency (local j.nr.: HGH-2016-052, I-Suite nr.: 04524) and by the Danish Health and Medicine Authority (nr. 3-3013-1588/1/)

Legal entity responsible for the study

Claus Larsen Feltoft

Funding

Department of Internal Medicine, Herlev and Gentofte Hospital (no specific grant number); Danish Cancer Society (grant number: R152-A9695-16-S7).

Disclosure

All authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences.