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Poster display session

1503 - Comparison of oxaliplatin-related spleen enlargement in patient with gastric cancer who received S-1 versus capecitabine as a combination partner of oxaliplatin

Date

09 Sep 2017

Session

Poster display session

Presenters

Seyoung Seo

Citation

Annals of Oncology (2017) 28 (suppl_5): v209-v268. 10.1093/annonc/mdx369

Authors

S. Seo1, M. Kim1, M.J. Kim2, M. Kim3, Y.I. Park3, S.R. Park1

Author affiliations

  • 1 Department Of Oncology, Asan Medical Center, University of Ulsan College of Medicine, 05505 - Seoul/KR
  • 2 Center For Colorectal Cancer, Research Institute and Hospital, National Cancer Center, 10408 - Goyang/KR
  • 3 Center For Gastric Cancer, Research Institute and Hospital, National Cancer Center, 10408 - Goyang/KR
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Resources

Abstract 1503

Background

Oxaliplatin (OX)-based chemotherapy is known to cause hepatic sinusoidal injury, resulting portal hypertension with splenomegaly (SM). We compared this OX-induced hepatopathy, SM, and their clinical significance according to combined oral fluoropyrimidines, S-1 vs. capecitabine (X) in gastric cancer (GC).

Methods

We analyzed pts from two prospective trials for GC, adjuvant XELOX (X 1000 mg/m2 bid on D1-14 + OX 130 mg/m2 on D1 q3w, 8 cycles; n = 52) and palliative SOX (S-1 40 mg/m2 bid on D1-14 + OX 130 mg/m2 on D1 q3w, continuous [SOX-c, n = 52] vs. intermittent [SOX-i, discontinuing after 6th and restarting on progression, n = 53]) Spleen volume (vol) was retrospectively measured by Rapidia software.

Results

Baseline sex, age, ECOG PS, BSA, spleen vol, levels of platelet (plt)/liver enzyme/bilirubin (bil) and OX cumulative dose during 8 cycles did not differ in XELOX and SOX-c. After 8 cycles, the SOX-c had more SM, hepatic enhancing heterogeneity, hyper-bil, and thrombocytopenia than the XELOX (Table). The SOX-c was a risk factor for developing SM (adjusted odds ratio, 4.7; 95% CI, 2.0-10.8; p

Conclusions

S-1 seems to enhance OX-induced hepatic sinusoidal injuries than capecitabine in pts with GC with clinical significance of higher incidences of splenomegaly, thrombocytopenia, and hyperbilirubinemia.

Clinical trial identification

Legal entity responsible for the study

Sook Ryun Park

Funding

None

Disclosure

All authors have declared no conflicts of interest.

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