Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Poster display session

4068 - Comparison of Breast Cancer Subtypes between young and elderly women

Date

11 Sep 2017

Session

Poster display session

Presenters

Ivane Kiladze

Citation

Annals of Oncology (2017) 28 (suppl_5): v595-v604. 10.1093/annonc/mdx391

Authors

I. Kiladze1, A. Mariamidze1, M. McHedlishvili2, K. Tsomaia2, F. Todua1

Author affiliations

  • 1 Medical Oncology, Research Institute of Clinical Medicine, 0112 - Tbilisi/GE
  • 2 Pathology, TSU, 0160 - Tbilisi/GE
More

Resources

Abstract 4068

Background

Breast cancer(BC) are increasingly recognized as heterogeneous disease based on expression of receptors for estrogen (ER), progesterone (PR), and human epidermal growth factor receptor 2 (HER2). There are four main subtypes of BC with differing tumor characteristics and different risk factors, treatment options and prognoses. Few data exist on the frequency of molecular subtypes in young and older women. The purpose of this study is to compare the distribution of the BC subtypes in young and elderly patients.

Methods

BC during the period 2013 to 2015 including ER/PR and HER2 status, was obtained from the Georgian main histopathology laboratories all over the country. We analyzed 1003 women with BC included 85 women aged 20 to 39 years (YA’s), 118 women aged 40 to 45 years (older premenopausal),665 women aged 46-70 (postmenopausal) and 135women older than 70 years (elderly group) at diagnosis. Incidence rates were calculated by subtype (triple-negative; HR +/HER2 -; HR +/HER2 +; HR -/HER2 +), and differences in subtype characteristics by age groups were evaluated.

Results

The incidence of BC in YA’s was 8,5%. The most common BC subtype was HR +/HER2- among all age groups, and HR -/HER2 + was the least; however, the relative contribution of each subtype varied within age categories. In YA’s HR +/HER2 - was the most commonly diagnosed subtype (62%), followed by HR +/HER2 + (15%), triple-negative (12%) and HR -/HER2 + (11%). Statistically no significant difference of BC subtypes was observed in age groups. HR +/HER2 - subtype was lesser in YA’s than in elder population (62% vs 73%), but statistically non-significant (p = 0.19) and there was not significant difference in prognostically “unfavorable” subtypes (HR-/HER2+ and triple-negative) (23% vs 17%) (p = 0.134; (CI) 95%: 0.09 to 1.71). Surprisingly no difference of Triple-negative BC was observed in YA and elderly groups (12% vs 13%).

Conclusions

The distribution of breast cancer subtypes among young adults didn’t vary from that observed in older women. Our study results seem to be in contradiction with other studies previously reported in literature. Future studies should consider whether distribution of breast cancer subtypes influences long-term survival in young compared with older women.

Clinical trial identification

GYO 02/17

Legal entity responsible for the study

Georgian Group of Young Oncologists

Funding

None

Disclosure

All authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences.