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Poster display session

1239 - Clinicopathologic features and long-term follow-up of metastatic gastrointestinal stromal tumor (GIST) patients (pts) with durable response (≥ 5 years) to frontline imatinib (IM): a case-control study from GEIS

Date

11 Sep 2017

Session

Poster display session

Presenters

Cesar Serrano

Citation

Annals of Oncology (2017) 28 (suppl_5): v521-v538. 10.1093/annonc/mdx387

Authors

C. Serrano1, A. Lopez Pousa2, I. Pajares3, C. Valverde Morales1, J. Duran4, J. Rubió-Casadevall5, M.J. Safont6, V. Martinez7, R. Díaz Beveridge8, A. Estival9, D. Vicente Baz10, A. Sebio Garcia2, N. Hindi11, S. Landolfi12, D. Olivares1, A. Garcia-Valverde1, P. Ledesma13, J. Arribas14, J. Carles Galceran1, J. Martin Broto11

Author affiliations

  • 1 Medical Oncology, Vall d'Hebron University Hospital, 08035 - Barcelona/ES
  • 2 Medical Oncology, Hospital de la Santa Creu i Sant Pau, 8026 - Barcelona/ES
  • 3 Medical Oncology, Hospital Miguel Servet, 50009 - Zaragoza/ES
  • 4 Medical Oncology, Hospital Universitario Son Espases, 07010 - Palma/ES
  • 5 Medical Oncology, Hospital Josep Trueta, Gerona/ES
  • 6 Medical Oncology, Hospital General de Valencia, Valencia/ES
  • 7 Medical Oncology, Hospital La Paz, Madrid/ES
  • 8 Medical Oncology, Hospital Universitari i Politècnic La Fe, 46026 - Valencia/ES
  • 9 Medical Oncology, Catalan Institute of Oncology (ICO Badalona), Hospital Germans Trias i Pujol, 8916 - Badalona/ES
  • 10 Medical Oncology, Hospital Universitario Virgen Macarena, 41003 - Sevilla/ES
  • 11 Medical Oncology, Hospital Universitario Virgen del Rocio, 41013 - Sevilla/ES
  • 12 Surgical Pathology, Vall d'Hebron University Hospital, 08035 - Barcelona/ES
  • 13 Sofpromed Investigación Clínica, GEIS, Palma/ES
  • 14 Preclinical Program, Vall d'Hebron University Hospital, 8035 - Barcelona/ES
More

Resources

Abstract 1239

Background

IM achieves disease control in most metastatic GIST pts, typically about 18 months. Interestingly, ∼15% GIST pts remain on IM beyond 5 years of continuous treatment. To date, clinicopathologic features predictive of long-term benefit to IM remain largely unknown.

Methods

We analyzed clinical, pathological and molecular characteristics, and long-term outcomes in metastatic GIST pts treated with continuous daily dosing of frontline IM in a cohort of pts benefiting ≥ 5 years, compared with a control group obtained from a national GEIS database.

Results

We found 41 IM long-term responders (IM-LTR) and 71 control cases (CC) with a median time on IM of 90.6 and 18.2 months, respectively. Compared to CC, IM-LTR were younger (59 vs 64 years, p = 0.040), fitter at diagnosis (performance status (PS) 0-1: 100% vs 82.2%, p 

Conclusions

Clinical and inherently biological tumor characteristics define a subset of GIST pts with increased likelihood to achieve durable benefit from IM. Molecular studies are needed to better identify these pts at treatment initiation.

Clinical trial identification

Legal entity responsible for the study

Spanish Group of Sarcoma Research (GEIS)

Funding

Spanish Group of Sarcoma Research (GEIS)

Disclosure

All authors have declared no conflicts of interest.

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