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Poster display session

1362 - Clinical implication of PLR and PD-L1 in breast cancer patients

Date

11 Sep 2017

Session

Poster display session

Presenters

Shusen Wang

Citation

Annals of Oncology (2017) 28 (suppl_5): v22-v42. 10.1093/annonc/mdx363

Authors

S. Wang1, Q. Lu2, T. Qin1, F. Xu1, Y. Zeng3, W. Xia1, Q. Zheng1, K. Lee1, K. Zhang1, G. Qin1, M.T. Kong4, R. Hong1, Y. Shi1, Z. Yuan1

Author affiliations

  • 1 Medical Oncology, Sun Yat-sen University Cancer Center, 510060 - Guangzhou/CN
  • 2 Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou/CN
  • 3 Breast Cencer, Sun Yat-sen Memorial Hospital, Guangzhou/CN
  • 4 Internal Medicine, Hospital Conde S. Januário, macau/MO
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Resources

Abstract 1362

Background

Anti-tumor action of the host immune systems and cancer-immune interaction are associated with tumor prognosis. Programmed death ligand-1 (PD-L1) expression was found as an unfavorable prognostic factor in breast cancer in our previous study. Besides, PD-L1 and biomarkers of the host immunity which included Neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) have been reported in predicting prognosis of biliary tract cancer. However, combination of NLR/PLR and PD-L1 in breast cancer has not been reported. The aim of this study is to evaluate the prognostic role of NLR/PLR and PD-L1 in breast cancer.

Methods

A total of 870 patients with breast cancer treated in Sun Yat-Sen University Cancer Center from 2000 to 2012 with known PD-L1 status were included. Clinicopathological data and pretreatment complete blood count were retrospectively collected. X-tile was used to generate the optimal cut-off value of NLR and PLR. Kaplan-Meier and univariate Cox proportional hazards model analyses were used to compare the survival of patients between different groups.

Results

High PLR group achieved worse result than low PLR group in OS and DFS (5-year OS rate: 82.6% vs 88.8%, p = 0.010; 5-year DFS rate: 78.7% vs 85.6%, p = 0.003). High PLR was associated with shorter DFS (adjusted HR = 1.540, 95%CI: 1.124-2.110, p = 0.007), while high PLR was not an independent factor for OS (adjusted HR = 1.001, 95%CI: 0.999-1.003, p = 0.488). NLR was not associated with patients’ survival outcome. And we found patients with PD-L1 expression and high PLR had the worst prognosis. The 5-year DFS rates were 68.4%, and 85.8% in high PLR+PD-L1 (+) group and low PLR+PD-L1 (-) group respectively (p = 0.002). The 5-year OS rates were 73.4% and 90.1%, respectively (p 

Conclusions

High PLR are associated with poor DFS in breast cancer patients. PD-L1 expression combined with high PLR was associated with an aggressive clinical outcome. Further studies are needed to evaluate the predictive value of combination of PD-L1 and peripheral blood immune markers.

Clinical trial identification

Legal entity responsible for the study

Shusen Wang

Funding

National Natural Science Foundation of China (81502302); Science and Technology Program of Guangdong Province (2014A020212384; 2016A020215079)

Disclosure

All authors have declared no conflicts of interest.

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