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Poster display session

2174 - Clinical factors associated with mutation burden in non-small cell lung cancer

Date

11 Sep 2017

Session

Poster display session

Presenters

Akira Ono

Citation

Annals of Oncology (2017) 28 (suppl_5): v573-v594. 10.1093/annonc/mdx390

Authors

A. Ono1, M. Serizawa2, K. Omae3, M. Isaka4, H. Kojima4, S. Takahashi4, K. Nakashima1, S. Omori1, K. Wakuda1, H. Kenmotsu1, T. Naito1, H. Murakami1, K. Urakami2, Y. Ohde4, T. Nakajima5, M. Kusuhara2, K. Yamaguchi6, T. Takahashi1

Author affiliations

  • 1 Thoracic Oncology, Shizuoka Cancer Center, 411-8777 - Shizuoka/JP
  • 2 Research Institute, Shizuoka Cancer Center, 411-8777 - Shizuoka/JP
  • 3 Clinical Research Promotion Unit, Shizuoka Cancer Center, 411-8777 - Shizuoka/JP
  • 4 Thoracic Surgery, Shizuoka Cancer Center, 411-8777 - Shizuoka/JP
  • 5 Diagnostic Pathology, Shizuoka Cancer Center, 411-8777 - Shizuoka/JP
  • 6 Hospital And Research Institute, Shizuoka Cancer Center, 411-8777 - Shizuoka/JP
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Resources

Abstract 2174

Background

PD-L1 expression is associated with clinical benefit from anti-PD1/anti-PD-L1 therapies in advanced NSCLC. However, additional biomarkers are needed to predict which patients will benefit most. The aim of this study is to correlate specific genomic alterations with immunological biomarkers in a cohort of NSCLC.

Methods

Patients diagnosed with NSCLC from 2000 to 2005 were retrospectively reviewed. Genetic mutations and copy number of selected genes were determined by Sanger and FISH. Immunophenotype was defined by PD-L1, HLA-1 and TILs CD8+ immunostaining and scored as follows: PD-L1 positivity ≥ 5% on membrane tumor cells; HLA-1 intensity: 0+,1+,2+; TILs CD8+ score: low or high infiltration. Statistical analysis using Chi-square test and logistic regression were performed.

Results

From 150 patients: 87% males; stage: 90% I-II, 10% III-IV; histology: 42% adenocarcinoma (ADC), 44% squamous (SCC), 14% sarcomatoid carcinoma (SaC). Genomic alterations according to histologic subtype are summarized in Table. PD-L1 was positive in 47% of tumors (49% of ADC, 43% of SCC, 58% of SaC), and correlated with TILs CD8 + (p

Conclusions

MET and STK11 alterations were correlated with differential expression of tumor PD-L1. STK11 mutant tumors were more likely to have an immunosupressive phenotype. Tumors harbouring specific genomic alterations might be enriched for distinct immunophenotypes which might contribute to rational use of immunotherapies.

Clinical trial identification

Legal entity responsible for the study

IDIBELL-Institut Català d'Oncologia

Funding

None

Disclosure

All authors have declared no conflicts of interest.

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