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Poster display session

2392 - Circulating tumor cells as prognostic marker in ovarian carcinoma. Results from the ANTHALYA study.

Date

09 Sep 2017

Session

Poster display session

Presenters

Thibault de La Motte Rouge

Citation

Annals of Oncology (2017) 28 (suppl_5): v330-v354. 10.1093/annonc/mdx372

Authors

T. de La Motte Rouge1, P. Cottu2, P. Pautier3, M. Provansal4, A. Floquet5, F. Selle6, M. Fabbro7, E. Kalbacher8, P. Follana9, A.F. Lesoin10, J. Medioni11, J. Dupin12, R. Ferri13, F. Bidard2, C. Dubot14, R. Rouzier15, F. Joly Lobbedez16

Author affiliations

  • 1 Medical Oncology, Centre Eugene - Marquis, 35042 - Rennes/FR
  • 2 Medical Oncology, Institut Curie, 75248 cedex5 - Paris/FR
  • 3 Medical Oncology, Gustave Roussy Institut de Cancérologie, 94805 - Villejuif/FR
  • 4 Medical Oncology, Institute Paoli Calmettes, 13274 - Marseille/FR
  • 5 Medical Oncology, Institute Bergonié, 33076 - Bordeaux/FR
  • 6 Medical Oncology, Groupe Hospitalier Diaconesse Croix Saint Simon, 75012 - PARIS/FR
  • 7 Medical Oncology, ICM Regional Cancer Institute of Montpellier, 34298 - Montpellier/FR
  • 8 Medical Oncology, CHU Besançon, Hôpital Jean Minjoz, 25030 - Besançon/FR
  • 9 Medical Oncology, Centre Antoine Lacassagne, 6100 - Nice/FR
  • 10 Medical Oncology, Centre Oscar Lambret, 59020 - Lille/FR
  • 11 Medical Oncology, Hopital European George Pompidou, 75015 - Paris/FR
  • 12 Statistics, ITM, 92650 - Boulogne Billancourt/FR
  • 13 Breast Gynaecological Cancers, ROCHE SAS, 92650 - Boulogne Billancourt/FR
  • 14 Medical Oncology, Hôpital René Huguenin - Institut Curie, 92210 - St. Cloud/FR
  • 15 Surgery, Hôpital René Huguenin - Institut Curie, 92210 - St. Cloud/FR
  • 16 Medical Oncology, Centre Francois Baclesse, 14076 - Caen/FR
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Resources

Abstract 2392

Background

Circulating tumor cells (CTC) are detected in 12–30% of advanced stage/relapsing ovarian carcinoma (OC). We evaluated the prognostic value of CTC counts among patients (pts) from the ANTHALYA trial, an open-label randomized phase II study evaluating addition of bevacizumab (Beva) to neoadjuvant carboplatin-paclitaxel (CP) in first line for pts with unresectable FIGO stage IIIc/IV ovarian, tubal or peritoneal adenocarcinoma.

Methods

We obtained CTC counts at baseline and before interval debulking surgery (IDS). A CTC threshold of ≥ 1 CTC/7.5 mL blood was considered as CTC+. We assessed the prognostic impact of CTCs on objective response rate (ORR), interval debulking surgery (IDS) rate, complete resection rate and progression-free survival (PFS), and explored their potential predictive impact on ORR and PFS according to bevacizumab therapy.

Results

In 88 pts with an available CTC count at baseline, CTC+ pts (n = 29) had a 75.9% ORR (at IDS), vs 59.3% for pts with 0 CTC (n = 59): OR = 2.2 [0.8-5.8] (OR-adj=1.8 [0.8-5.8]). Respectively, 58.6% vs 66.1% were amenable to IDS and 55.2% vs 54.2% achieved a complete resection. Median PFS was 21 m [15.0-25.4] in CTC+ pts and 25.8 m [18.5-27.2] in pts with 0 CTC (HR = 1.5 [0.8-2.8] and HR-adj=1.7 [0.9-3.2]). CTC counts at IDS were available in 70 pts. At IDS, a complete resection was achieved in 66.7% of CTC+ pts (n = 6), and in 68.8% of pts with 0 CTC (n = 64). Exploration of the potential predictive impact of CTC is described in the table.Table:

947P

Prognostic approach0 CTC at baseline (n = 59)CTC+ at baseline (n = 29)
ORR at IDS59.3%75.9%
Median PFS [95% CI]25.8 m [18.5-27.2]21.0 m [15.0-25.4]
Predictive approachBeva (n = 36)CP (n = 23)Beva (n = 17)CP (n = 12)
ORR at IDS61.1%56.5%82.4%66.7%
Median PFS [95% CI]25.8 [20.9-NE]20.3 [13.8-27.2]21.0 [15.0-30.6]20.6 [8.0-25.4]
Progression rate at M3636.1%56.5%52.9%83.3%

Conclusions

Baseline CTC counts in OC patients receiving neoadjuvant chemotherapy +/- bevacizumab carry dual prognostic information: CTC count at IDS do not add any information, CTC+ seems to be associated with a higher ORR, while 0 CTC count seems to be a prognostic factor with better PFS, in the whole population and among patients treated with bevacizumab.

Clinical trial identification

2012-01144-22

Legal entity responsible for the study

ROCHE

Funding

Roche

Disclosure

T. de La Motte Rouge: Consultancy work: AstraZeneca, Roche, MSD, Eisai, Sanofi Travel grants/meeting support: Roche, Novartis, Pfizer Corporate-sponsored research: Novartis. P. Cottu: Novartis, Roche, AstraZeneca, Nanostring, Pfizer. P. Pautier: Membership on an advisory board or board of directors: Roche: Travel grants/meeting support: Roche, Astra Zeneca, Pharmamar Corporate-sponsored research; Pharmamar, Novartis. A. Floquet: Membership on an advisory board or board of directors: Roche, AstraZeneca; Travel grants/meeting support: Roche, AstraZeneca. F. Selle: Consultancy work: Roche: Travel grants/meeting support: Roche, AstraZeneca, Pharmamar. M. Fabbro: Travel grants/meeting support: Roche. E. Kalbacher: Travel grants/meeting support: Roche, Pharmamar, GSK, Leo Pharma, AstraZeneca. P. Follana: Consultancy work: AstraZeneca, Novartis Travel grants/meeting support: Roche, AstraZeneca, Amgen. A.F. Lesoin: Employment: Centre Oscar Lambret, Lille. J. Medioni: Membership on an advisory board or board of directors: AstraZeneca, Pierre Fabre Consultancy work: Clovis Oncology; Travel grants/meeting support: Roche, Sanofi Aventis. J. Dupin: Employment: Roche. R-M. Ferri: Employment: Roche SAS. C. Dubot: Corporate-sponsored research: Roche. R. Rouzier: Membership on an advisory board or board of directors: Roche; Consultancy work: Roche; Travel grants/meeting support: Roche; Corporate-sponsored research: Roche. F. Joly Lobbedez: Consultancy work: AstraZeneca, Janssen, Tesaro, Roche, Sanofi, Novartis, Bristol-Myers Squib Travel grants/meeting support: Roche, Janssen, AstraZeneca, Tesaro Corporate-sponsored research: Astellas, Janssen. All other authors have declared no conflicts of interest.

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