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Poster display session

3510 - Characterization of cachectic patients with non-small cell lung cancer (NSCLC) according to their modified Glasgow Prognostic Score (mGPS)

Date

10 Sep 2017

Session

Poster display session

Presenters

Barry Laird

Citation

Annals of Oncology (2017) 28 (suppl_5): v497-v501. 10.1093/annonc/mdx382

Authors

B. Laird1, D. McMillan2, S. Kaasa3, M. Fallon4, R. Skipworth5, D. Currow6, R. Giorgino7

Author affiliations

  • 1 Institute Of Genetics And Molecular Medicine, University of Edinburgh, EH4 2XR - Edinburgh/GB
  • 2 Academic Unit Of Surgery, New Lister Building, Glasgow Royal Infirmary, University of Glasgow, Glasgow/GB
  • 3 Department Of Oncology, Oslo University Hospital and University of Oslo, Oslo/NO
  • 4 Institute Of Genetics And Molecular Medicine, University of Edinburgh, Edinburgh/GB
  • 5 Clinical Surgery, University of Edinburgh, Edinburgh/GB
  • 6 Impacct – Improving Palliative Aged And Chronic Care Through Clinical Research And Translation, Faculty Of Health, University of Technology Sydney, 2007 - Sydney/AU
  • 7 Research And Development Innovation And Strategy Department, Helsinn Healthcare, Lugano/CH
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Resources

Abstract 3510

Background

Patients with advanced NSCLC often develop anorexia/cachexia, a comorbidity characterized by decreased body weight or low body mass index (BMI), which negatively impacts quality of life and life expectancy. Weight loss and BMI were suggested to have independent prognostic value (Martin L et al, JCO 2015). The mGPS (0–2) has independent prognostic value, where patients with mGPS 2 (C-reactive protein levels >10mg/L and albumin levels

Methods

Patients with unresectable stage III/IV NSCLC and cachexia (BMI

Results

At baseline, 36% patients had mGPS 0 (n = 296), 49% mGPS 1 (n = 396) and 15% mGPS 2 (n = 123). Patients who lost 10% body weight, a higher percentage had mGPS 2. Patients with mGPS 2 had on average substantially lower values of body weight, body composition parameters, handgrip strength and anorexia/cachexia and fatigue scores than the other mGPS subgroups (Table).Table:

1392P

Baseline characteristics based on mGPS score
mGPS 0 (n = 296)mGPS 1 (n = 396)mGPS 2 (n = 123)
Body weight loss, n (%) ≤ 10% > 10%205 (43.0) 92 (27.1)218 (45.7) 178 (52.5)54 (11.3) 69 (20.4)
Mean body weight, kg (SD)66.9 (13.66)67.4 (12.73)63.0 (13.77)
Mean lean body mass, kg (SD)44.9 (8.64)46.2 (7.78)44.5 (8.54)
Mean appendicular lean body mass, kg (SD)19.3 (4.59)19.7 (3.95)18.4 (4.25)
Mean fat mass, kg (SD)19.4 (8.06)19.0 (7.80)16.3 (8.01)
Mean handgrip strength, kg (SD)32.2 (11.74)32.7 (10.92)27.2 (9.91)
Mean FAACT Anorexia/Cachexia subscale score (SD)31.6 (7.92)29.5 (8.16)25.5 (8.77)
Mean fatigue subscale score (SD)32.4 (9.74)30.6 (10.21)25.4 (10.95)

FAACT, Functional Assessment of Anorexia/Cachexia Therapy; mGPS, modified Glasgow prognostic score; SD, standard deviation.

Conclusions

While patients with cachexia present mGPS scores that vary from 0–2, a higher percentage of patients with mGPS 2 was observed among those with >10% body weight loss. The baseline characteristics observed in patients with mGPS 2 are worse than in the other mGPS subgroups, suggesting that mGPS may be helpful in identifying patients with more-advanced cachexia.

Clinical trial identification

ROMANA 1: NCT01387269 ROMANA 2: NCT01387282

Legal entity responsible for the study

Helsinn

Funding

Helsinn

Disclosure

B. Laird: Advisory board membership: Chugai Pharma. S. Kaasa: Stock ownership: Eir solutions AS. R. Skipworth: Corporate-sponsored research: Research grant/agreement with Novartis. D. Currow: Unpaid advisory board member for Helsinn. Paid consultant and receive payment for intellectual property with Mayne Pharma and am a consultant with Specialist Therapeutics Australia Pty. Ltd. R. Giorgino: Helsinn Healthcare employee. All other authors have declared no conflicts of interest.

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