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Supportive and palliative care

3599 - Cancer cachexia (CAX), anorexia and muscle wasting (sarcopenia) assessment in non-small cell lung cancer (NSCLC): an observational study in 531 patients

Date

09 Sep 2017

Session

Supportive and palliative care

Presenters

Didier Debieuvre

Citation

Annals of Oncology (2017) 28 (suppl_5): v497-v501. 10.1093/annonc/mdx382

Authors

D. Debieuvre1, H. Morel2, P. Souquet3, V. Surmont4, D. Planchard5, F. Bonnetain6, I. Krakowski7, H. Gaudin8, S. Antoun9

Author affiliations

  • 1 Department Of Pneumology, Hôpital Emile Muller, 68070 - Mulhouse/FR
  • 2 Department Of Pneumology, C.H.R. Orleans - La Source, 45067 - Orleans/FR
  • 3 Department Of Pneumology, Centre Hospitalier Lyon Sud, 69495 - Pierre Bénite/FR
  • 4 Department Of Thoracic Oncology, Gent University Hospital, 9000 - Gent/BE
  • 5 Department Of Medical Oncology, GUSTAVE ROUSSY, 94805 - Villejuif/FR
  • 6 Methodological And Quality Of Life Unit In Oncology (inserm Umr 1098), CHRU Besançon Jean Minjoz, 25000 - Besançon/FR
  • 7 Département Interdisciplinaire De Soins De Support Pour Le Patient En Oncologie. (disspo-care), Institut Bergonié, 33076 - Bordeaux/FR
  • 8 Medical Affairs, Chugai Pharma France, 92042 - Paris/FR
  • 9 Unité De Médecine Aigue En Oncologie, Institut Gustave Roussy, 94805 - Villejuif/FR
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Abstract 3599

Background

Since publications highlighting the role of sarcopenia, weight loss (WL) is no longer the corner stone of malnutrition assessment. An international consensus proposed in 2011 a definition and a staging of CAX, mainly based on WL, sarcopenia, inflammation and anorexia (Fearon). We initiated this study to fill the gap of epidemiological data on CAX in NSCLC in France and Belgium.

Methods

This cross-sectional, prospective, multicentric study was conducted in Patients (pts) with NSCLC regardless of the tumor stage and the treatment line. Skeletal muscle mass (SMM) was assessed by analyzing L3 CT-scan image. Pts completed Anorexia/CAX subscale of FAACT and EORTC QLQ-C30 health related quality of life (QoL) questionnaires. Primary endpoint was the frequency of CAX according to Fearon criteria. Secondary endpoints were the frequency and the characteristics of the other stages of CAX focusing on early and discrete malnutrition changes (pre-CAX).

Results

539 NSCLC pts were recruited within 3 months in 2016 by 56 sites, analysis population was of 531 pts and 312 had SMM assessment. Median age was 66 years, 66.5% were males, 79.9% were PS 

Conclusions

This is the first study showing an association between molecular abnormality in NSCLC and cachexia. It has also shown that it may be useful to detect sarcopenia in pts with limited WL (

Clinical trial identification

NCT02968979, First received: November 17, 2016

Legal entity responsible for the study

Chugai Pharma France

Funding

Chugai Pharma France

Disclosure

D. Debieuvre, P-J. Souquet, S. Antoun: Corporate-sponsored research: Chugai-Pharma France. H. Morel: Corporate-sponsored research: Chugai Pharma France, Roche, Astra, Lilly, MSD, Pfizer, BMS, amgen. V. Surmont: Corporate-sponsored research: Chugai-Pharma France. D. Planchard: Corporate-sponsored consultancy: AstraZeneca, Boehringer Ingelheim, BMS, Lilly, MSD, Pfizer, Roche, Novartis, Chugai Pharma France. F. Bonnetain: corporate-sponsored research: Chugai Pharma France, Amgen, Roche, Merck Serono, Nestlé, Ipsen, Jansen. I. Krakowski: Membership on an advisory board and/or symposium: Chugai Pharma France, Kyowa kirin, Pfizer, Astellas, Janssen, Takeda, P Fabre. H. Gaudin: Employee of Chugai Pharma France.

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