Since publications highlighting the role of sarcopenia, weight loss (WL) is no longer the corner stone of malnutrition assessment. An international consensus proposed in 2011 a definition and a staging of CAX, mainly based on WL, sarcopenia, inflammation and anorexia (Fearon). We initiated this study to fill the gap of epidemiological data on CAX in NSCLC in France and Belgium.
This cross-sectional, prospective, multicentric study was conducted in Patients (pts) with NSCLC regardless of the tumor stage and the treatment line. Skeletal muscle mass (SMM) was assessed by analyzing L3 CT-scan image. Pts completed Anorexia/CAX subscale of FAACT and EORTC QLQ-C30 health related quality of life (QoL) questionnaires. Primary endpoint was the frequency of CAX according to Fearon criteria. Secondary endpoints were the frequency and the characteristics of the other stages of CAX focusing on early and discrete malnutrition changes (pre-CAX).
539 NSCLC pts were recruited within 3 months in 2016 by 56 sites, analysis population was of 531 pts and 312 had SMM assessment. Median age was 66 years, 66.5% were males, 79.9% were PS
This is the first study showing an association between molecular abnormality in NSCLC and cachexia. It has also shown that it may be useful to detect sarcopenia in pts with limited WL (
Clinical trial identification
NCT02968979, First received: November 17, 2016
Legal entity responsible for the study
Chugai Pharma France
Chugai Pharma France
D. Debieuvre, P-J. Souquet, S. Antoun: Corporate-sponsored research: Chugai-Pharma France. H. Morel: Corporate-sponsored research: Chugai Pharma France, Roche, Astra, Lilly, MSD, Pfizer, BMS, amgen. V. Surmont: Corporate-sponsored research: Chugai-Pharma France. D. Planchard: Corporate-sponsored consultancy: AstraZeneca, Boehringer Ingelheim, BMS, Lilly, MSD, Pfizer, Roche, Novartis, Chugai Pharma France. F. Bonnetain: corporate-sponsored research: Chugai Pharma France, Amgen, Roche, Merck Serono, Nestlé, Ipsen, Jansen. I. Krakowski: Membership on an advisory board and/or symposium: Chugai Pharma France, Kyowa kirin, Pfizer, Astellas, Janssen, Takeda, P Fabre. H. Gaudin: Employee of Chugai Pharma France.