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Poster display session

4754 - CORE-URO-01 study: comparison of safety and efficacy of pazopanib in first-line metastatic renal cell carcinoma (mRCC) with or without renal failure

Date

10 Sep 2017

Session

Poster display session

Presenters

Cristina Masini

Citation

Annals of Oncology (2017) 28 (suppl_5): v295-v329. 10.1093/annonc/mdx371

Authors

C. Masini1, M.G. Vitale1, M. Maruzzo2, G. Procopio3, U. De Giorgi4, S. Buti5, S. Rossetti6, R. Iacovelli7, A. Guida8, F. Atzori9, C. Mucciarini10, S. Scagliarini11, F. Vignani12, G. Prati13, L. Cosmai14, A. Berselli1, C. Pinto1

Author affiliations

  • 1 Oncology Unit, Azienda Ospedaliera Arcispedale Santa Maria Nuova - IRCCS, 42100 - Reggio Emilia/IT
  • 2 Oncology Unit, Istituto Oncologico Veneto IRCCS, 35128 - Padova/IT
  • 3 Oncology Unit, FONDAZIONE IRCCS INT MILANO, 20133 - Milano/IT
  • 4 Oncology Unit, Istituto Tumori della Romagna I.R.S.T., 47014 - Meldola/IT
  • 5 Oncology Unit, Azienda Ospedaliera di Parma, 43126 - Parma/IT
  • 6 Division Of Medical Oncology, Department Of Uro-gynaecological Oncology, Istituto Nazionale Tumori – I.R.C.C.S - Fondazione Pascale, 80131 - Napoli/IT
  • 7 Oncology Unit, Azienda ospedaliero universitaria integrata Verona, 37134 - Verona/IT
  • 8 Oncology Unit, Azienda Ospedaliero - Universitaria Policlinico di Modena, 41100 - Modena/IT
  • 9 Oncology Unit, azienda ospedaliera-universitaria di Cagliari, 09100 - Cagliari/IT
  • 10 Medical Oncology, Ramazzini Hospital, 41012 - Carpi (Modena)/IT
  • 11 Oncology Unit, Azienda ospedaliera Antonio Cardarelli, 80131 - Napoli/IT
  • 12 Oncology Unit, A.O. Ordine Mauriziano, 10128 - Torino/IT
  • 13 Medical Oncology, A.O. Ordine Mauriziano, 42016 - Guastalla/IT
  • 14 Nephrology Unit, Istituti Ospitalieri Cremona, 26100 - Cremona/IT
More

Resources

Abstract 4754

Background

Pazopanib has been approved for first-line treatment of patients (pts) with mRCC based on the prospective randomized trial that enrolled only pts with adequate renal function. There are no data on the efficacy and toxicity of pazopanib in pts with renal insufficiency (RI). The aim of this study is to investigate the effect of kidney function on treatment outcomes in pts treated with pazopanib for mRCC.

Methods

We retrospectively analyzed the data of the mRCC pts treated with pazopanib with respect to renal function in fourteen Italian institutions from January 2010 to June 2016. Baseline glomerular filtration rate (GFR) was calculated using the Modification of Diet in Renal Disease (MDRD) formula at the time of therapy initiation. Pts with MDRD

Results

Two hundred and twenty-nine pts with mRCC were included in this study: 128 pts in group A and 101 pts in group B. 68% of pts were male, median age was 67 years (34-88) and median CrCl was 49,7 ml/min in group A. In group B, 64% of pts were male, median age was 64 years (38-85) and median CrCl was 74 ml/min. Pts with MDRD

Conclusions

Although in this study it is necessary to reduce the dose of pazopanib more frequent in pts with RI, kidney function at therapy initiation does not adversely affect the efficacy and safety of pazopanib.

Clinical trial identification

Legal entity responsible for the study

Cristina Masini

Funding

None

Disclosure

All authors have declared no conflicts of interest.

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