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Poster display session

5401 - Baseline neutrophil-to-lymphocyte ratio and its values monitored over time is associated with outcome of metastatic melanoma patients treated with immunotherapy

Date

10 Sep 2017

Session

Poster display session

Presenters

Iwona Lugowska

Citation

Annals of Oncology (2017) 28 (suppl_5): v428-v448. 10.1093/annonc/mdx377

Authors

I. Lugowska1, B. Cybulska-Stopa2, P. Jagodzinska-Mucha1, P. Teterycz1, H. Koseła-Paterczyk1, K. Kozak1, K. Szamotulska3, K. Roman2, T. Switaj1, M. Ziobro2, P. Rutkowski1

Author affiliations

  • 1 Soft Tissue/bone Sarcoma And Melanoma, The Maria Sklodowska-Curie Memorial Institute and Oncology Centre, 02-781 - Warsaw/PL
  • 2 Systemic Neoplasm, The Maria Sklodowska-Curie Memorial Institute and Oncology Centre, 310115781 - Krakow/PL
  • 3 Biostatistics, Institute of Mother and Child, 02495 - Warszawa/PL
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Resources

Abstract 5401

Background

Neutrophil-to-lymphocyte ratio (N/L) was shown to be prognostic in several solid malignancies. There are limited data about changes of N/L ratios during immunotherapy. The aim of the study was to asses a clinical value of this ratio and its association with tumour response in patients with advanced melanoma.

Methods

Between June 2011 and March 2017, 308 patients with metastatic/unresectable melanoma were included to the analysis. Patients age was 58.4±17.3 years (mean), 43 cases had brain metastases. BRAF mutation was present in 107 cases, and 98 patients with positive mutation received targeted therapies with BRAF+/- MEK followed by ipilumumab and/or anti-PD1 therapy. Patients with BRAF negative mutation received immunotherapy (pembrolizumab or nivolumab with/without ipilimumab). In all patients the N/L ratio was assessed at the baseline and monitored during treatment until disease progression or last observation. The cut off for ratio N/L was set at 3. Logistic GEE and Kaplan-Meier survival probability estimation were used for analysis.

Results

N/L ratio ≥3 at baseline was significantly associated with poorer overall survival (OS) (p 

Conclusions

Our results confirm the usefulness of N/L ratio as a prognostic and predictive marker in patients with metastatic melanoma, and monitoring of the N/L ratio over immunotherapy may be helpful for assessment of the disease progression, response, as well as pseudoprogression, thus likely contributes to an optimization of treatment and resource allocation in patients with metastatic melanoma.

Clinical trial identification

not applicable

Legal entity responsible for the study

Maria Sklodowska-Curie Institute and Oncology Center, Warsaw, Poland

Funding

None

Disclosure

B. Cybulska-Stopa, H. Koseła-Paterczyk: Personal fees for lectures from Novartis, Roche, Bristol-Myers Squibb, MSD. K. Kozak: Personal fees for lectures from Novartis, Roche, Bristol-Myers Squibb and MSD. P. Rutkowski: Reports personal fees from Novartis, Bristol-Myers Squibb, Roche, MSD, GSK, Amgen - lecture honoraria and membership of Advisory outside the submitted work. All other authors have declared no conflicts of interest.

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