Abstract 1849
Background
Enterolignans are important biomarkers of microbiome diversity. Higher levels, indicating greater diversity, have been shown to reduce cancer risk. Diet and inflammation have been shown to play a role in maintaining microbiome diversity. This study examined whether inflammatory potential of diet, as measured by the Dietary Inflammatory IndexTM (DII) has an impact on levels of urinary enterolignans in the National Health and Nutrition Examination Survey (NHANES) 2003-2008. We also carried out validation of the DII with C-reactive protein (CRP).
Methods
Data came from NHANES 2003-2008. Enterolignans (enterodiol and enterolactone) and CRP were assayed from urine and serum specimens, respectively. DII scores were calculated from food intakes assessed using 24-hour dietary recalls and expressed per 1,000 calories consumed. Associations were examined using survey-based multivariable linear and logistic regression.
Results
After adjustment, higher DII scores (i.e., relatively more pro inflammatory) were associated with lower levels of creatinine normalized enterodiol (bDIIquartile4vs1 = -1.22; 95% CI = -0.69, -1.74; Ptrend =
Conclusions
In these NHANES data, there was an association between DII and enterolignans. This study also provided a successful construct validation of the DII using CRP in a nationally representative sample. Using enterolignans as a proxy for gut microbiome, these results indicate that diet-associated inflammation modifies gut diversity.
Clinical trial identification
Legal entity responsible for the study
University of South Carolina
Funding
NIH.
Disclosure
N. Shivappa, M. Wirth, J. Hebert: Dr. James R. Hébert owns controlling interest in Connecting Health Innovations LLC (CHI), a company planning to license the right to his invention of the dietary inflammatory index (DII). Drs. Nitin Shivappa and Michael Wirth are employees of CHI. All other authors have declared no conflicts of interest.