Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Poster display session

1849 - Association between the Dietary Inflammatory Index (DII), urinary enterolignans and C-reactive protein in the National Health and Nutrition Examination Survey-2003-2008

Date

11 Sep 2017

Session

Poster display session

Presenters

Nitin Shivappa

Citation

Annals of Oncology (2017) 28 (suppl_5): v573-v594. 10.1093/annonc/mdx390

Authors

N. Shivappa1, M. Wirth1, A. Murphy2, T. Hurley1, J. Hebert1

Author affiliations

  • 1 Epidemiology, university of south carolina, 29210 - Columbia/US
  • 2 Pathology, university of south carolina, 29209 - Columbia/US
More

Resources

Abstract 1849

Background

Enterolignans are important biomarkers of microbiome diversity. Higher levels, indicating greater diversity, have been shown to reduce cancer risk. Diet and inflammation have been shown to play a role in maintaining microbiome diversity. This study examined whether inflammatory potential of diet, as measured by the Dietary Inflammatory IndexTM (DII) has an impact on levels of urinary enterolignans in the National Health and Nutrition Examination Survey (NHANES) 2003-2008. We also carried out validation of the DII with C-reactive protein (CRP).

Methods

Data came from NHANES 2003-2008. Enterolignans (enterodiol and enterolactone) and CRP were assayed from urine and serum specimens, respectively. DII scores were calculated from food intakes assessed using 24-hour dietary recalls and expressed per 1,000 calories consumed. Associations were examined using survey-based multivariable linear and logistic regression.

Results

After adjustment, higher DII scores (i.e., relatively more pro inflammatory) were associated with lower levels of creatinine normalized enterodiol (bDIIquartile4vs1 = -1.22; 95% CI = -0.69, -1.74; Ptrend = 

Conclusions

In these NHANES data, there was an association between DII and enterolignans. This study also provided a successful construct validation of the DII using CRP in a nationally representative sample. Using enterolignans as a proxy for gut microbiome, these results indicate that diet-associated inflammation modifies gut diversity.

Clinical trial identification

Legal entity responsible for the study

University of South Carolina

Funding

NIH.

Disclosure

N. Shivappa, M. Wirth, J. Hebert: Dr. James R. Hébert owns controlling interest in Connecting Health Innovations LLC (CHI), a company planning to license the right to his invention of the dietary inflammatory index (DII). Drs. Nitin Shivappa and Michael Wirth are employees of CHI. All other authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences.