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Poster display session

4665 - Additive effect of Vinca Alkaloids as the Risk Factor for Hearing Impairments in the Childhood Cancer Survivors

Date

10 Sep 2017

Session

Poster display session

Presenters

Lily Myung-Jin Cha

Citation

Annals of Oncology (2017) 28 (suppl_5): v543-v567. 10.1093/annonc/mdx388

Authors

L.M. Cha1, M. Huh1, J.Y. Lim2, S.M. Hahn2, C.J. Lyu2, J.W. Han1

Author affiliations

  • 1 Department Of Pediatric Hemato-oncology, Yonsei Cancer Center, 03722 - SEOUL/KR
  • 2 Department Of Pediatric Hemato-oncology, Yonsei Cancer Center, SEOUL/KR
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Resources

Abstract 4665

Background

The survival rate of childhood cancer is approaching to over 80%, and survivorship is gathering more attention. The survivors receive chemotherapy, radiotherapy and surgery in their early life stages, and the risk of ototoxicity is increased. We evaluated the degree of risk of the clinical factors causing the ototoxicy, in childhood cancer survivors.

Methods

We established survivorship program for late effects in Yonsei Cancer Center, Seoul, Korea. In all 531 enrolled survivors in the clinic, 105 patients were invited to evaluate otoxocitity in their bi-annual visits and the clinical risk factors were reviewed retrospectively.

Results

The median age at diagnosis was 6.0 (0∼26). Most common diagnosis was leukemia/lymphoma (N = 30, 30%), and brain tumor was the next (N = 29, 29%). Platinum agents were used in 64%, alkylating agents was in 83% and vinca alkaloid was in 78%. Severe hearing impairments defined as over than 60 dB loss were observed in 37% of left ears and 39% of right ears. The proportion of the survivors who had 20 dB loss in any side of ears was 28%. The 69% of abdomen tumor survivors and 56% of brain tumors had any of hearing impairments, but only 28% of leukemia/lymphoma survivors showed hearing loss (P 

Conclusions

Hearing impairments were common late effects in childhood cancer survivors, and vinca alkaloids had additive adverse effects on the platinum use for the hearing loss.

Clinical trial identification

Legal entity responsible for the study

Jung Woo Han

Funding

None

Disclosure

All authors have declared no conflicts of interest.

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