The incidence and risk factor of delayed chemotherapy-induced nausea and vomiting (CINV) for colorectal cancer (CRC) patients receiving oxaliplatin-based chemotherapy has not been clearly controlled. To evaluate the efficacy and risk factor of combination antiemetic treatment for delayed CINV in CRC patients receiving oxaliplatin-based chemotherapy.
Aggregated data were pooled from the two prospective observational studies and one clinical trial; A nationwide survey of CINV study group, the other prospective observational study in Japan and SENRI Trial in Japan. We assessed whether delayed CINV were controlled with 3 antiemetic treatment. We also evaluated risk factors by logistic regression analysis.
A total of 661 patients were evaluable in this study. The median age was 64 (range:19-85) with 391males and 270 females. Three antiemetics were used in 220 (33.3%) patients. Delayed CINV were experienced more commonly in women than in men. Delayed nausea was well controlled with 3 antiemetics than with 2 antiemetics for women (38.3% vs. 52.8%; P=0.0295). Delayed vomiting was well controlled with 3 antiemetics than with 2 antiemetics for overall (4.1% vs. 15.9%; P
Three antiemetics combination are encouraged for CRC female patients treated with oxaliplatin-based chemotherapy to alleviate delayed CINV. Identification of individual risk factors will assist in the development of personalized treatments for delayed CINV.
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All authors have declared no conflicts of interest.