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Poster display session

873 - A pooled analysis evaluating the combination antiemetic therapy on chemotherapy-induced nausea and vomiting in patients with colorectal cancer receiving oxaliplatin-based chemotherapy of moderate emetic risk

Date

10 Sep 2017

Session

Poster display session

Presenters

Mototsugu Shimokawa

Citation

Annals of Oncology (2017) 28 (suppl_5): v543-v567. 10.1093/annonc/mdx388

Authors

M. Shimokawa1, T. Kogawa2, J. Nishimura3, T. Satoh4, K. Nakata5, T. Hayashi6, R. Matsui7, K. Aiba8, K. Tamura9

Author affiliations

  • 1 Clinical Research Institute, National Kyushu Cancer Center, 811-1395 - Fukuoka/JP
  • 2 Department Of Developmental Therapeutics, National Cancer Center Hospital East, Kashiwa/JP
  • 3 Department Of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Suita/JP
  • 4 Department Of Frontier Science For Cancer And Chemotherapy, Graduate School of Medicine, Osaka University, Suita/JP
  • 5 Department Of Surgery, Sakai city medical center, Sakai/JP
  • 6 Department Of Pharmacy, National Kyushu Medical Center, Fukuoka/JP
  • 7 Department Of Pharmacy, National Cancer Center Hospital East, 277-8577 - Kashiwa/JP
  • 8 Division Of Clinical Oncology/hematology, The Jikei University School of Medicine, 105-8461 - Tokyo/JP
  • 9 General Medical Research Center, Fukuoka University, Fukuoka/JP
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Resources

Abstract 873

Background

The incidence and risk factor of delayed chemotherapy-induced nausea and vomiting (CINV) for colorectal cancer (CRC) patients receiving oxaliplatin-based chemotherapy has not been clearly controlled. To evaluate the efficacy and risk factor of combination antiemetic treatment for delayed CINV in CRC patients receiving oxaliplatin-based chemotherapy.

Methods

Aggregated data were pooled from the two prospective observational studies and one clinical trial; A nationwide survey of CINV study group, the other prospective observational study in Japan and SENRI Trial in Japan. We assessed whether delayed CINV were controlled with 3 antiemetic treatment. We also evaluated risk factors by logistic regression analysis.

Results

A total of 661 patients were evaluable in this study. The median age was 64 (range:19-85) with 391males and 270 females. Three antiemetics were used in 220 (33.3%) patients. Delayed CINV were experienced more commonly in women than in men. Delayed nausea was well controlled with 3 antiemetics than with 2 antiemetics for women (38.3% vs. 52.8%; P=0.0295). Delayed vomiting was well controlled with 3 antiemetics than with 2 antiemetics for overall (4.1% vs. 15.9%; P

Conclusions

Three antiemetics combination are encouraged for CRC female patients treated with oxaliplatin-based chemotherapy to alleviate delayed CINV. Identification of individual risk factors will assist in the development of personalized treatments for delayed CINV.

Clinical trial identification

Legal entity responsible for the study

N/A

Funding

None

Disclosure

All authors have declared no conflicts of interest.

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