This study investigated the predictive value of the tumor-associated neutrophil-to-lymphocyte ratio (TA-NLR) on clinical outcomes for patients with gastric neuroendocrine neoplasms (g-NENs) after radical surgery.
Data from 142 patients who were diagnosed with g-NENs and underwent radical gastrectomy at our department from March 2006 to March 2015 were prospectively collected and retrospectively analyzed. Receiver operating characteristic curve analysis was used to identify the optimal value for TA-NLR. Univariate and multivariate survival analysis were used to identify prognostic factors for g-NENs. A nomogram was adopted to predict RFS and OS after surgery.
TA-NLR was not significantly associated with clinical characteristics (all P > 0.05). TA-NLR significantly correlated with tumor recurrence, especially with liver and lymph node metastasis (both P
TA-NLR was an independent prognostic factor for patients with g-NENs regarding RFS and OS. Nomograms with the TA-NLR, Ki-67 index and lymph node ratio had a superior ability to predict clinical outcomes for postoperative g-NENs patients, as well as the traditional TNM staging system.
Clinical trial identification
Legal entity responsible for the study
All authors have declared no conflicts of interest.