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Poster display session

1560 - 68Ga-PSMA-PET/CT as a changing practice tool in biochemically recurrent prostate cancer

Date

10 Sep 2017

Session

Poster display session

Presenters

Pedro Domingues

Citation

Annals of Oncology (2017) 28 (suppl_5): v269-v294. 10.1093/annonc/mdx370

Authors

P.M. Domingues1, T. Abreu2, M.B. Siqueira3, G. Marinho1, D. Rosa1, H. Cottas1, L.H. Araujo1, D. Herchenhorn2, F.A. Peixoto1

Author affiliations

  • 1 Medical Oncology, INSTITUTO COI- CLINICAS ONCOLOGICAS INTEGRADAS, 22793-080 - RIO DE JANEIRO/BR
  • 2 Medical Oncology, oncologia DOR, 011 - rio de janeiro/BR
  • 3 Medical Oncology, oncoclinica, 22640000 - RIO DE JANEIRO/BR
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Resources

Abstract 1560

Background

PSMA-PET/CT have demonstrated interesting results in the detection of loco-regional and distant disease in prostate cancer patients with biochemical relapse. Even with low levels of PSA, PSMA imaging is able to identify metastatic lesions, being a possible tool for tailoring treatment decisions. This study aims to describe the use of PSMA-PET/CT in the daily practice and its clinical impact in the management of prostate cancer patients who have rising PSA after curative treatment.

Methods

We performed a retrospective analysis in 29 localized prostate cancer patients of three private Brazilian cancer institutions who underwent PSMA-PET/CT for rising PSA after treatment with curative intent. The clinical impact of PSMA-PET/CT was evaluated by whether the assistant physician changed or not the treatment strategy based solely on PSMA results. In addition, modifications related to local (salvage radiotherapy [SRT], salvage lymphadenectomy [SL]) and systemic (antiandrogen deprivation therapy [ADT], chemotherapy [chemo]) treatment were described.

Results

In total, 29 patients were enrolled. Twenty-seven (93%) had undergone radical prostatectomy, and 2 (7%) radiotherapy as the local curative treatment. Sixteen cases (55%) had not received any radiotherapy previously. The mean Gleason score, PSA level and PSADT at time of the examination were 8, 4.2 (0,05-41) ng/ml and 4.4 (0.4-27) months, respectively. PSMA-PET/CT detected at least one suspicious lesion for prostate cancer in 21/29 (58%) patients. Overall, 15/29 (51%) patients had their treatment strategy changed due to results in PSMA imaging. In only 3/29 (10%) the modifications were related exclusively to systemic protocols (1 avoided ADT, 1 added ADT and, 1 added chemo). Whereas in the 12/29 (41%) remaining cases, treatment strategy change involved local treatment. Of these 12 with a local treatment change, 7 added (6 SL, 1 SRT) and 5 avoided (5 SRT) local therapies.

Conclusions

Half of the patients with biochemical relapse that underwent PSMA-PET/CT had their treatment protocol changed, most changes related to local treatment. Although the role of PSMA imaging is not clearly defined, PSMA-PET/CT has been used as a practice changing tool in the daily practice.

Clinical trial identification

Legal entity responsible for the study

Instituto COI

Funding

None

Disclosure

All authors have declared no conflicts of interest.

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