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Poster Display

2780 - Use of bevacizumab (Bev) in real life for first-line (fl) treatment of ovarian cancer (OC). Part1: the ENCOURAGE cohort of 1158 patients (pts) by GINECO


08 Oct 2016


Poster Display


Dominique Berton-Rigaud


Annals of Oncology (2016) 27 (6): 296-312. 10.1093/annonc/mdw374


D. Berton-Rigaud1, F. Selle2, A. Floquet3, D. Mollon4, W. Lescaut5, M. Kaminsky6, I.L. Ray-Coquard7, R. Largillier8, A. Savoye9, H. Barletta10, P. Pautier11, H. Orfeuvre12, M. Baron13, A. Marti14, J. Mouysset15, J. Paoli16, P. Cailleux17, C. Cornea18, E. Pujade-Lauraine19

Author affiliations

  • 1 Oncologie, ICO Centre René Gauducheau, 44805 - Saint-Herblain/FR
  • 2 Oncologie Médicale, Hôpital Tenon, Paris/FR
  • 3 Oncologie Médicale, Institute Bergonié, Bordeaux/FR
  • 4 Service Radiothérapie Et Oncologie Médicale, CH de Cornouaille - Hopital Laennec, Quimper/FR
  • 5 Service De Médecine Interne Hématologie Oncologie, Centre Hospitalier Princesse Grâce CHPG-Monaco, Monaco/MC
  • 6 Oncologie Médicale, ICL Institut de Cancérologie de Lorraine, Vandoeuvre les Nancy/FR
  • 7 Service 2b Nord, Centre Léon Bérard, Lyon/FR
  • 8 Oncologie Médicale, Centre Azuréen de Cancérologie, Mougins/FR
  • 9 Service Rubis - Oncologie Médicale, Institut Jean Godinot, Reims/FR
  • 10 Cancérologie Médicale, Hôpital Privé Drôme Ardèche - Clinique Pasteur, GUILHERAND-GRANGES/FR
  • 11 Oncologie Médicale, Centre Léonard de Vinci, Dechy/FR
  • 12 Service Onco-hématologie, Centre Hospitalier de Bourg-en-Bresse (Fleyriat) CH De Fleyriat, Bourg en Bresse/FR
  • 13 Oncologie Médicale, Clinique Mathilde, Rouen/FR
  • 14 Service Oncologie, CH Auxerre, Auxerre/FR
  • 15 Oncologie, Clinique Provençale, Aix-en-Provence/FR
  • 16 Oncologie, Hôpital Saint-Joseph, Marseille/FR
  • 17 Oncologie, Pôle Santé Léonard de Vinci, Chambray-lès-Tours/FR
  • 18 Oncologie, Centre Hospitalier Jean Bernard, Valenciennes/FR
  • 19 Cancer De La Femme Et Recherche Clinique, AP-HP, Hôpitaux Universitaires Paris Centre site Hôtel-Dieu, 75004 - Paris/FR


Abstract 2780


Bev has obtained European (EU) approval for EOC pts treated in fl on 12/2011. This study addresses the question of how Bev is used in routine practice for the fl treatment of OC pts.


102 centers were selected to be representative of the distribution of OC pts in France. All consecutive OC pts treated in fl in each center were screened in order to include at least 500 pts who gave their consent to participate to the ENCOURAGE cohort evaluating the long term Bev use in routine practice. We report here how Bev was prescribed in this series of pts.


From 04/2013 to 02/2015, 1158 evaluable pts representing 15% of French incidence cases were screened in academic hospital (15%), cancer center (29%), general hospital (25%), private center (31%). Bev was administered in 557 (48%) pts and mostly according to the label: with carboplatin (99%) and paclitaxel (98%), for stage IIIB-IV (97%), and at a dose of 15mg/kg (80.2%). Bev was NOT prescribed in 601/1158 pts and reasons were specified for 487pts. These were comorbidity including age over 70 (29%), neo-adjuvant strategy (22%), early stage (20%), inclusion in a trial (13%), no macroscopic residue after initial surgery (11%), early disease progression or death (3%), patient refusal (2%). Interestingly, in this series of 1158 consecutive pts, only about 1/3 of pts with comorbidity/age over 70, or no residue after initial surgery or treated with a neo-adjuvant strategy were excluded from Bev treatment, reflecting the heterogeneity of practice among centers.


Bev was administered in 1st line EOC treatment according to the EU label for the great majority of pts . However, the large variability of Bev prescription when patients had comorbidity, age over 70 or were treated with a neo-adjuvant strategy reflects the need of OC trials focusing on these populations of patients.

Clinical trial identification


Legal entity responsible for the study





J-L. Mouysset: Roche, Astellas, Sanofi, Janssen, Hospira, Novartis, Sandoz, Pierre Fabre. All other authors have declared no conflicts of interest.

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