Abstract 3587
Background
Previous epidemiological studies have shown that diabetes mellitus (DM), alcohol, smoking and pancreatic cancer (PC) in close relatives are risk factors for developing PC. We investigated if these known risk factors are associated with short overall survival (OS) in patients with PC.
Methods
629 patients with pancreatic ductal adenocarcinoma (PDAC) (M/F 346/283, stage I (n = 22), stage II (n = 183), stage III (90) and stage IV (n = 334)) and 53 patients with ampullary adenocarcinoma (AAC) (M/F 32/20, stage I (n = 11), stage II (n = 26), stage III (13) and stage IV (n = 3)) were included from 6 hospitals in the Danish BIOPAC project from July 2008 to April 2016. Baseline clinical characteristics, IDDM, NIDDM, patient's history of cancer or family history of cancer were retrospectively registered and analyzed. Hazard ratios (HR) were estimated for OS by means of Cox proportional hazards model.
Results
117 (19%) of the PDAC and 5 (11%) of the AAC patients had known IDDM or NIDDM at time of diagnosis. 471 (69%) had family history of cancer; most common types were breast cancer (7%), colorectal cancer (6.7%), lung cancer (6.7%), PC (6%) and uterus (3.4%). 36.7% were former smokers and 30% were current smokers. 25% had previous or present high alcohol intake. Known IDDM and NIDDM at time of diagnosis were associated with short OS (HR = 1.52, 95% CI 1.11-2.07, p = 0.01 and HR = 1.36, 95% CI 1.00-1.83, p = 0.05, respectively). Present or previous high alcohol intake, tobacco use, family history of cancer or own earlier cancer or gastrointestinal inflammation were not associated with poor prognosis.
Conclusions
In this Danish multicenter study we demonstrated that known IDDM and NIDDM at time of diagnosis were the only risk factors associated with poor prognosis.
Clinical trial identification
BIOPAC, version 3, 16 february 2016
Approved by the National Committee on Health Research Ethics
(VEK nr. KA-20060113)
The Danish Data Protection Agency
(j.nr.2012-58-0004; HGH-2015-027; I-Suite nr: 03960)
Legal entity responsible for the study
The National Committee on Health Research Ethics The Danish Data Protection Agency
Funding
N/A
Disclosure
All authors have declared no conflicts of interest.
Resources from the same session
ZUMA-3: A phase 1/2 multi-center study evaluation the safety and efficacy of KTE-C19 anti-CD19 CAR T cells in adult patients with relapsed/refractory B precursor acute lymphoblastic leukemia (R/R ALL)
Presenter: Bijal Shah
Session: Poster display
Resources:
Abstract
ZUMA-2: A phase 2 multi-center study evaluating the efficacy of KTE-C19 (Anti-CD19 CAR T cells) in patients with relapsed/refractory Mantle cell lymphoma (R/R MCL)
Presenter: Michael Wang
Session: Poster Display
Resources:
Abstract
ZUMA-1: A phase 2 multi-center study evaluating anti-CD19 chimeric antigen receptor (CAR) T cells in patients with refractory aggressive non-Hodgkin lymphoma (NHL)
Presenter: Sattva Neelapu
Session: Poster Display
Resources:
Abstract
Younger age as a prognostic indicator in breast cancer: Correlation between clinical-pathologic factors and miRNAs and long-term follow-up
Presenter: Maria Teresa Martinez
Session: Poster display
Resources:
Abstract
Window study of the PARP inhibitor rucaparib in patients with primary triple negative or BRCA1/2 related breast cancer (RIO)
Presenter: Christy Toms
Session: Poster display
Resources:
Abstract
Whole exome sequencing (WES) and RNA sequencing (RNA-seq) in routine clinical practice for colorectal cancer (CRC) and non-small cell lung cancer (NSCLC) patients (pts)
Presenter: Géraldine Perkins
Session: Poster display
Resources:
Abstract
What is the optimal annual interpretive volume for a radiologist reading screening mammograms?
Presenter: Asli Uluturk
Session: Poster display
Resources:
Abstract
What decides breast conservation versus mastectomy in the background of diverse sociocultural environment, an Indian study
Presenter: Poonamalle Padmanabhan Bapsy
Session: Poster display
Resources:
Abstract
Waiting time to diagnosis and treatment of the head and neck cancer in four institutions in Portugal
Presenter: Ana Castro
Session: Poster display
Resources:
Abstract
Wait times for diagnosis and treatment of lung cancer: a single centre experience
Presenter: Catherine Labbe
Session: Poster Display
Resources:
Abstract