The impact of delay in adjuvant radiotherapy in the combined modality treatment of early stage breast cancer: single institutional experience

Date

10 Oct 2016

Session

Poster display

Presenters

Mai Ezz El Din

Citation

Annals of Oncology (2016) 27 (6): 43-67. 10.1093/annonc/mdw364

Authors

M. Ezz El Din, D. Abd El Ghany

Author affiliations

  • Clinical Oncology, Ain Shams University Faculty of Medicine, 11566 - Cairo/EG
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Resources

Background

To study how the timing of radiation influences local control, disease-free survival (DFS) and overall survival (OS) in patients being treated with chemotherapy and radiation for early stage carcinoma of the breast.

Methods

In this retrospective study the medical records of patients who received adjuvant chemotherapy and radiotherapy (RT) for early stage breast cancer (I- II) after definitive surgery at the department of Clinical Oncology, Ain Shams University Hospitals were collected and reviewed.

Results

Between 2007 and 2009, 118 patients were collected and included for analysis. Patients were divided into 2 groups: Group A consisted of 56 patients that started adjuvant RT 2 and lymph node positive disease predicted for worse DFS (p = 0.05) and OS (p = 0.006).

Conclusions

In patients requiring chemotherapy and radiation treatments for early stage breast cancer, a delay in the initiation of radiation for a period exceeding 6 months from diagnosis resulted in a higher local failure rate. Furthermore, this higher local failure rate was associated with an increased rate of distant metastases and a reduced overall survival rate.

Clinical trial identification

This abstract was accepted for IMPAKT 2016 # 225. Hope we have better luck. Thank you.

Legal entity responsible for the study

Ain Shams University

Funding

Ain Shams University

Disclosure

All authors have declared no conflicts of interest.

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